Activating Transcription Factor 4 (ATF4)

TAXREB67; TXREB; CREB-2; DNA-binding protein TAXREB67; Cyclic AMP-responsive element-binding protein 2; Tax-responsive enhancer element-binding protein 67

SPN	V449
HGNC	786
MGI	88096
PubMed	23874395
RGD	621863
UniProt	P18848
Wiki	ATF4

Activating transcription factor 4 is  a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA-binding domain. Two alternative transcripts encoding the same protein have been described.

Reference

"Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I."
J. Virol. 65:1420-1426(1991) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element."
Proc. Natl. Acad. Sci. U.S.A. 89:4820-4824(1992) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers."
Genes Dev. 3:2083-2090(1989) [PubMed] [Europe PMC] [Abstract]

Erratum
Genes Dev. 4:682-682(1990)

"TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death."
EMBO J. 24:1243-1255(2005) [PubMed] [Europe PMC] [Abstract]

"FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice."
J. Cell Biol. 169:591-601(2005) [PubMed] [Europe PMC] [Abstract]

"The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4."
Nat. Genet. 38:674-681(2006) [PubMed] [Europe PMC] [Abstract]

"C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene."
J. Biol. Chem. 283:35106-35117(2008) [PubMed] [Europe PMC] [Abstract]

"Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome."
J. Proteome Res. 9:6298-6316(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform."
PLoS ONE 6:E17344-E17344(2011) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA."
J. Biol. Chem. 276:505-513(2001) [PubMed] [Europe PMC] [Abstract]