B-Lymphocyte Activation Antigen B7-1 (LAB7-1)

CD80; CD28LG; CD28LG1; BB1; B7-1 Antigen; T-lymphocyte activation antigen CD80; CTLA-4 counter-receptor B7.1

SPN	V448
HGNC	1700
MGI	101775
PubMed	12015893
RGD	2314
UniProt	P33681
Wiki	CD80

The protein CD80 is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.1. Its principal mode of action is by binding to CD28. Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells. CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells. Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells.  

Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. Acts as a receptor for adenovirus subgroup B.

Reference

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"CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL."
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"Interaction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation."
Immunology 98:413-421(1999) [PubMed] [Europe PMC] [Abstract]

"Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors."
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Immunity 12:51-60(2000) [PubMed] [Europe PMC] [Abstract]

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Nature 410:608-611(2001) [PubMed] [Europe PMC] [Abstract]