Activating Transcription Factor 7 (ATF7)

ATFA; Cyclic AMP-Dependent Transcription Factor ATF-7

SPN	V436
HGNC	792
MGI	2443472
PubMed	15906372
RGD	1304940
UniProt	P17544
Wiki	ATF7

Activating transcription factors (ATFs), or cAMP response element-binding proteins (CREBs), bind to cAMP-inducible promoters and are involved in gene transcription. By screening a HeLa cell cDNA library using an adenovirus ATF-binding sequence as the probe, Gaire et al. (1990) isolated cDNAs encoding ATF7, which they called ATFA, and a splice variant. The predicted 483-amino acid full-length phosphoprotein contains a leucine zipper preceded by a region rich in positively charged amino acids and is homologous to ATF2 . Compared with full-length ATF7, the splice variant lacks residues 114 to 134. atf7b is maternally expressed and during embryogenesis its mRNA is ubiquitously distributed, showing an expression pattern similar to that of mammalian Atf7.

Reference

"Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells."
Nucleic Acids Res. 18:3467-3473(1990) [PubMed] [Europe PMC] [Abstract]

"ATF-a0, a novel variant of the ATF/CREB transcription factor family, forms a dominant transcription inhibitor in ATF-a heterodimers."
J. Biol. Chem. 269:1159-1165(1994) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity."
Proc. Natl. Acad. Sci. U.S.A. 88:3720-3724(1991) [PubMed] [Europe PMC] [Abstract]

"Transcriptional activation by the adenovirus larger E1a product is mediated by members of the cellular transcription factor ATF family which can directly associate with E1a."
Mol. Cell. Biol. 13:561-570(1993) [PubMed] [Europe PMC] [Abstract]

"Jun and Fos heterodimerize with ATFa, a member of the ATF/CREB family and modulate its transcriptional activity."
Oncogene 9:375-385(1994) [PubMed] [Europe PMC] [Abstract]

"Role of the ATFa/JNK2 complex in Jun activation."
Oncogene 18:3491-3500(1999) [PubMed] [Europe PMC] [Abstract]

"A functional interaction between ATF7 and TAF12 that is modulated by TAF4."
Oncogene 24:3472-3483(2005) [PubMed] [Europe PMC] [Abstract]

"Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity."
Nucleic Acids Res. 35:1134-1144(2007) [PubMed] [Europe PMC] [Abstract]

"p38beta2-mediated phosphorylation and sumoylation of ATF7 are mutually exclusive."
J. Mol. Biol. 384:980-991(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"A cytoplasmic negative regulator isoform of ATF7 impairs ATF7 and ATF2 phosphorylation and transcriptional activity."
PLoS ONE 6:E23351-E23351(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]