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Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4)

CD85k; LILR-B4; LILRB5; HM18; ILT3; LIR-5; Immunoglobulin-like transcript 3; Leukocyte immunoglobulin-like receptor 5; CD85 antigen-like family member K

Leukocyte immunoglobulin-like receptor subfamily B member 4is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).
The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV435Hu01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV435Hu01 Monoclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) WB; IHC; ICC; IP.
PAV435Hu01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) WB; IHC; ICC; IF.
Assay Kits CLV435Hu01 CLIA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) CLIA assay for Antigen Detection
ELV435Hu01 ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV435Mu01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV435Mu01 Monoclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) WB; IHC; ICC; IP.
PAV435Mu01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) WB; IHC; ICC; IF.
Assay Kits CLV435Mu01 CLIA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) CLIA assay for Antigen Detection
ELV435Mu01 ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV435Ra01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV435Ra01 Monoclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) WB; IHC; ICC; IP.
PAV435Ra01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) WB; IHC; ICC; IF.
Assay Kits CLV435Ra01 CLIA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) CLIA assay for Antigen Detection
ELV435Ra01 ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV435Ca01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV435Ca01 Monoclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) WB; IHC; ICC; IP.
PAV435Ca01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) WB; IHC; ICC; IF.
Assay Kits CLV435Ca01 CLIA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) CLIA assay for Antigen Detection
ELV435Ca01 ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV435Po01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV435Po01 Monoclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) WB; IHC; ICC; IP.
PAV435Po01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) WB; IHC; ICC; IF.
Assay Kits CLV435Po01 CLIA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) CLIA assay for Antigen Detection
ELV435Po01 ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV435Bo01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV435Bo01 Monoclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) WB; IHC; ICC; IP.
PAV435Bo01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) WB; IHC; ICC; IF.
Assay Kits CLV435Bo01 CLIA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) CLIA assay for Antigen Detection
ELV435Bo01 ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV435Rb01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV435Rb01 Monoclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) WB; IHC; ICC; IP.
PAV435Rb01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) WB; IHC; ICC; IF.
Assay Kits CLV435Rb01 CLIA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) CLIA assay for Antigen Detection
ELV435Rb01 ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV435Mo01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV435Mo01 Monoclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) WB; IHC; ICC; IP.
PAV435Mo01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) WB; IHC; ICC; IF.
Assay Kits CLV435Mo01 CLIA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) CLIA assay for Antigen Detection
ELV435Mo01 ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor."
J. Immunol. 159:2342-2349(1997) [PubMed] [Europe PMC] [Abstract]

"A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules."
J. Immunol. 159:5192-5196(1997) [PubMed] [Europe PMC] [Abstract]

"Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4."
Immunogenetics 51:659-669(2000) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing."
J. Exp. Med. 185:1743-1751(1997) [PubMed] [Europe PMC] [Abstract]

"Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4."
Nat. Immunol. 3:237-243(2002) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance."
J. Biol. Chem. 286:18013-18025(2011) [PubMed] [Europe PMC] [Abstract]