Fc Fragment Of IgA Receptor (FcaR)
CD89; FcaRI; Receptor I For The Fc Region Of Immunoglobulin A; IgA Fc receptor; Immunoglobulin alpha Fc receptor
Only one Fc receptor belongs to the Fc alpha R subgroup, which is called Fc alpha RI (or CD89). Fc alpha RI is found on the surface of neutrophils, eosinophils, monocytes, some macrophages (including Kupffer cells), and some dendritic cells. It is composed of two extracellular Ig-like domains, and is a member of both the immunoglobulin superfamily and the multi-chain immune recognition receptor (MIRR) family. It signals by associating with two FcR gamma，signaling chains.
Another receptor can also bind IgA, although it has higher affinity for another antibody called IgM. This receptor is called the Fc-alpha/mu receptor (Fc alpha/mu R) and is a type I transmembrane protein. With one Ig-like domain in its extracellular portion, this Fc receptor is also a member of the immunoglobulin superfamily.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV432Hu01 | Recombinant Fc Fragment Of IgA Receptor (FcaR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV432Hu01 | Monoclonal Antibody to Fc Fragment Of IgA Receptor (FcaR) | WB; IHC; ICC; IP. |
| PAV432Hu01 | Polyclonal Antibody to Fc Fragment Of IgA Receptor (FcaR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV432Hu01 | CLIA Kit for Fc Fragment Of IgA Receptor (FcaR) | CLIA assay for Antigen Detection |
| ELV432Hu01 | ELISA Kit for Fc Fragment Of IgA Receptor (FcaR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV432Mu01 | Recombinant Fc Fragment Of IgA Receptor (FcaR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV432Mu01 | Monoclonal Antibody to Fc Fragment Of IgA Receptor (FcaR) | WB; IHC; ICC; IP. |
| PAV432Mu01 | Polyclonal Antibody to Fc Fragment Of IgA Receptor (FcaR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV432Mu01 | CLIA Kit for Fc Fragment Of IgA Receptor (FcaR) | CLIA assay for Antigen Detection |
| ELV432Mu01 | ELISA Kit for Fc Fragment Of IgA Receptor (FcaR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV432Ra01 | Recombinant Fc Fragment Of IgA Receptor (FcaR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV432Ra01 | Monoclonal Antibody to Fc Fragment Of IgA Receptor (FcaR) | WB; IHC; ICC; IP. |
| PAV432Ra01 | Polyclonal Antibody to Fc Fragment Of IgA Receptor (FcaR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV432Ra01 | CLIA Kit for Fc Fragment Of IgA Receptor (FcaR) | CLIA assay for Antigen Detection |
| ELV432Ra01 | ELISA Kit for Fc Fragment Of IgA Receptor (FcaR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV432Ca01 | Recombinant Fc Fragment Of IgA Receptor (FcaR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV432Ca01 | Monoclonal Antibody to Fc Fragment Of IgA Receptor (FcaR) | WB; IHC; ICC; IP. |
| PAV432Ca01 | Polyclonal Antibody to Fc Fragment Of IgA Receptor (FcaR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV432Ca01 | CLIA Kit for Fc Fragment Of IgA Receptor (FcaR) | CLIA assay for Antigen Detection |
| ELV432Ca01 | ELISA Kit for Fc Fragment Of IgA Receptor (FcaR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV432Po01 | Recombinant Fc Fragment Of IgA Receptor (FcaR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV432Po01 | Monoclonal Antibody to Fc Fragment Of IgA Receptor (FcaR) | WB; IHC; ICC; IP. |
| PAV432Po01 | Polyclonal Antibody to Fc Fragment Of IgA Receptor (FcaR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV432Po01 | CLIA Kit for Fc Fragment Of IgA Receptor (FcaR) | CLIA assay for Antigen Detection |
| ELV432Po01 | ELISA Kit for Fc Fragment Of IgA Receptor (FcaR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV432Bo01 | Recombinant Fc Fragment Of IgA Receptor (FcaR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV432Bo01 | Monoclonal Antibody to Fc Fragment Of IgA Receptor (FcaR) | WB; IHC; ICC; IP. |
| PAV432Bo01 | Polyclonal Antibody to Fc Fragment Of IgA Receptor (FcaR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV432Bo01 | CLIA Kit for Fc Fragment Of IgA Receptor (FcaR) | CLIA assay for Antigen Detection |
| ELV432Bo01 | ELISA Kit for Fc Fragment Of IgA Receptor (FcaR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV432Rb01 | Recombinant Fc Fragment Of IgA Receptor (FcaR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV432Rb01 | Monoclonal Antibody to Fc Fragment Of IgA Receptor (FcaR) | WB; IHC; ICC; IP. |
| PAV432Rb01 | Polyclonal Antibody to Fc Fragment Of IgA Receptor (FcaR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV432Rb01 | CLIA Kit for Fc Fragment Of IgA Receptor (FcaR) | CLIA assay for Antigen Detection |
| ELV432Rb01 | ELISA Kit for Fc Fragment Of IgA Receptor (FcaR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV432Mo01 | Recombinant Fc Fragment Of IgA Receptor (FcaR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV432Mo01 | Monoclonal Antibody to Fc Fragment Of IgA Receptor (FcaR) | WB; IHC; ICC; IP. |
| PAV432Mo01 | Polyclonal Antibody to Fc Fragment Of IgA Receptor (FcaR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV432Mo01 | CLIA Kit for Fc Fragment Of IgA Receptor (FcaR) | CLIA assay for Antigen Detection |
| ELV432Mo01 | ELISA Kit for Fc Fragment Of IgA Receptor (FcaR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Expression cloning of a human Fc receptor for IgA."
J. Exp. Med. 172:1665-1672(1990) [PubMed] [Europe PMC] [Abstract]
"Structure of the gene for the human myeloid IgA Fc receptor (CD89)."
J. Immunol. 155:1203-1209(1995) [PubMed] [Europe PMC] [Abstract]
"Identification of Fc alpha receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages."
J. Immunol. 156:4442-4448(1996) [PubMed] [Europe PMC] [Abstract]
"Alternative splicing of the human IgA Fc receptor CD89 in neutrophils and eosinophils."
Biochem. J. 318:771-777(1996) [PubMed] [Europe PMC] [Abstract]
"IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells."
Clin. Exp. Immunol. 110:226-232(1997) [PubMed] [Europe PMC] [Abstract]
"Episodes of natural selection shaped the interactions of IgA-Fc with FcalphaRI and bacterial decoy proteins."
J. Immunol. 178:7943-7954(2007) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Association of IgA-Fc receptors (Fc alpha R) with Fc epsilon RI gamma 2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of gamma 2."
J. Immunol. 153:3228-3236(1994) [PubMed] [Europe PMC] [Abstract]
"An unappreciated role for RNA surveillance."
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the ectodomain of human FcalphaRI."
J. Biol. Chem. 278:27966-27970(2003) [PubMed] [Europe PMC] [Abstract]
"Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc."
Nature 423:614-620(2003) [PubMed] [Europe PMC] [Abstract]