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Lipopolysaccharide Binding Protein (LBP)
Lipopolysaccharide Binding Protein (LBP)
LPS-Binding Protein
LPS-binding protein (LBP) is serum factor known to regulate the endotoxin-induced cellular immune response. Sepsis is a morbid condition induced by a toxin, the introduction or accumulation of which is most commonly caused by infection or trauma. Sepsis-inducing toxins have been found associated with pathogenic bacteria, viruses, plants and venoms.
Among the well described bacterial toxins are the endotoxins or lipopolysaccharides (LPS) of the gram-negative bacteria. Upon introduction of LPS into the blood it binds to lipopolysaccharide binding protein (LBP). LBP recognizes the lipid A region of LPS and forms high affinity complexes with both rough and smooth form LPS. During the acute phase, LBP is synthesized by hepatocytes, and reaches very high concentrations in serum.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
V428Mu01
Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipopolysaccharide Binding Protein (LBP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
PV428Mu01
Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry;ICC/IF
Assay Kits
KEV428Mu
ELISA Kit for Lipopolysaccharide Binding Protein (LBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipopolysaccharide Binding Protein (LBP) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipopolysaccharide Binding Protein (LBP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipopolysaccharide Binding Protein (LBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipopolysaccharide Binding Protein (LBP) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
Organism species: Bos taurus; Bovine (Cattle)
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipopolysaccharide Binding Protein (LBP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipopolysaccharide Binding Protein (LBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipopolysaccharide Binding Protein (LBP) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipopolysaccharide Binding Protein (LBP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipopolysaccharide Binding Protein (LBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipopolysaccharide Binding Protein (LBP) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipopolysaccharide Binding Protein (LBP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipopolysaccharide Binding Protein (LBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipopolysaccharide Binding Protein (LBP) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
V428Rb01
Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipopolysaccharide Binding Protein (LBP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
PV428Rb51
Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipopolysaccharide Binding Protein (LBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipopolysaccharide Binding Protein (LBP) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipopolysaccharide Binding Protein (LBP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipopolysaccharide Binding Protein (LBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipopolysaccharide Binding Protein (LBP) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipopolysaccharide Binding Protein (LBP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipopolysaccharide Binding Protein (LBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipopolysaccharide Binding Protein (LBP) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipopolysaccharide Binding Protein (LBP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipopolysaccharide Binding Protein (LBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipopolysaccharide Binding Protein (LBP) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipopolysaccharide Binding Protein (LBP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipopolysaccharide Binding Protein (LBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipopolysaccharide Binding Protein (LBP) CLIA assay for Antigen Detection
Reference
"Structure and function of lipopolysaccharide binding protein." Science 249:1429-1431(1990) [PubMed ] [Europe PMC ] [Abstract ]
"Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation." J. Biol. Chem. 269:17411-17416(1994) [PubMed ] [Europe PMC ] [Abstract ]
"The genomic organization of the genes for human lipopolysaccharide binding protein (LBP) and bactericidal permeability increasing protein (BPI) is highly conserved." Biochem. Biophys. Res. Commun. 236:427-430(1997) [PubMed ] [Europe PMC ] [Abstract ]
"Similar organization of the lipopolysaccharide-binding protein (LBP) and phospholipid transfer protein (PLTP) genes suggests a common gene family of lipid-binding proteins." Genomics 46:416-425(1997) [PubMed ] [Europe PMC ] [Abstract ]
"Cloning and sequencing of human lipopolysaccharide-binding protein gene." Sheng Wu Hua Xue Yu Sheng Wu Wu Li Jin Zhan 25:469-471(1998)
"Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed ] [Europe PMC ] [Abstract ]
"The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed ] [Europe PMC ] [Abstract ]
"Structural biology of the LPS recognition." Int. J. Med. Microbiol. 297:353-363(2007) [PubMed ] [Europe PMC ] [Abstract ]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." J. Proteome Res. 8:651-661(2009) [PubMed ] [Europe PMC ] [Abstract ]
"The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity." Immunity 39:647-660(2013) [PubMed ] [Europe PMC ] [Abstract ]