Cluster Of Differentiation 97 (CD97)

TM7LN1; TM7-LN1; Seven-Span Transmembrane Protein; Seven-Transmembrane,Heterodimeric Receptor Associated With Inflammation; Seven Transmembrane Helix Receptor

SPN	V424
HGNC	1711
MGI	1347095
PubMed	12417446
RGD	1305595
UniProt	P48960
Wiki	CD97

CD97 antigen is a glycoprotein that is present on the surface of most activated leukocytes and spans the membrane seven times, which is a defining feature of G protein-coupled receptors. The protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade.

The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing has been observed for this gene and three variants have been found.

Reference

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J. Immunol. 155:1942-1950(1995) [PubMed] [Europe PMC] [Abstract]

"Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily."
Genomics 32:144-147(1996) [PubMed] [Europe PMC] [Abstract]

"CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation."
J. Immunol. 157:5438-5447(1996) [PubMed] [Europe PMC] [Abstract]

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