Nucleoporin 210kDa (NUP210)

POM210; gp210; Nuclear Pore Glycoprotein 210; Nuclear envelope pore membrane protein POM 210; Pore membrane protein of 210 kDa

SPN	V413
HGNC	30052
MGI	1859555
PubMed	22264802
RGD	69339
UniProt	Q8TEM1
Wiki	NUP210

Nuclear pore glycoprotein-210 (gp210) is an essential trafficking regulator in the eukaryotic nuclear pore complex. Gp-210 anchors the pore complex to the nuclear membrane. and protein tagging reveals its primarily located on the luminal side of double layer membrane at the pore. A single polypeptide motif of gp210 is responsible for sorting to nuclear membrane, and indicate the carboxyl tail of the protein is oriented toward the cytoplasmic side of the membrane.The deduced protein contains 1,886 amino acids. Northern blot analysis detected a 7.5-kb transcript. In situ hybridization detected preferential expression in epithelial cells. In kidney, expression was seen in both the epithelium derived from the ureteric tree and the mesenchyme-derived epithelium.

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