Early B-Cell Factor 1 (EBF1)

COE1; EBF; O/E-1; OLF1; Transcription Factor COE1

SPN	V412
HGNC	3126
MGI	95275
PubMed	24174531
RGD	620953
UniProt	Q9UH73
Wiki	EBF1

Early B-cell factor (EBF) is a tissue-specific and differentiation stage-specific DNA-binding protein that participates in the regulation of the pre-B and B lymphocyte-specific MB1 gene. It is composed of two 62- to 65-kD subunits. Using partial amino acid sequences of Ebf to isolate mouse pre-B-cell cDNAs encoding Ebf, the predicted 591-amino acid protein has 2 functional domains: an N-terminal cysteine-rich region essential for DNA binding, and a C-terminal dimerization region containing two 15-amino acid repeats with similarity to the dimerization domains of basic helix-loop-helix (bHLH) proteins. The calculated molecular mass of the encoded Ebf protein is 64.4 kD.

Reference

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning of human early B-cell factor and identification of target genes suggest a conserved role in B-cell development in man and mouse."
Blood 96:1457-1464(2000) [PubMed] [Europe PMC] [Abstract]

"Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells."
Blood 103:2062-2070(2004) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"Structural determination of functional domains in early B-cell factor (EBF) family of transcription factors reveals similarities to Rel DNA-binding proteins and a novel dimerization motif."
J. Biol. Chem. 285:25875-25879(2010) [PubMed] [Europe PMC] [Abstract]