Cluster Of Differentiation 99 (CD99)

MIC2X; MIC2Y; MIC2; Antigen Identified By Monoclonal Antibodies 12E7,F21 And O13; E2 antigen; T-cell surface glycoprotein E2

SPN	V408
HGNC	7082
MGI	1913728
PubMed	15469477
UniProt	P14209
Wiki	CD99

CD99 is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma.

Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Two transcript variants encoding different isoforms have been found for this gene.It is expressed on all leukocytes but highest on thymocytes and is believed to augment T-cell adhesion,apoptosis of double positive t cells,and participates in migration and activation.

Reference

"The E2 antigen, a 32 kd glycoprotein involved in T-cell adhesion processes, is the MIC2 gene product."
EMBO J. 8:3253-3259(1989) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular genetics of MIC2: a gene shared by the human X and Y chromosomes."
Cold Spring Harb. Symp. Quant. Biol. 51:205-212(1986) [PubMed] [Europe PMC] [Abstract]

"Absence of methylation of a CpG-rich region at the 5' end of the MIC2 gene on the active X, the inactive X, and the Y chromosome."
Proc. Natl. Acad. Sci. U.S.A. 85:5605-5609(1988) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]