Adenylate Cyclase 9 (ADCY9)

AC9; ATP pyrophosphate-lyase 9; Adenylate cyclase type IX

SPN	V407
HGNC	240
MGI	108450
PubMed	11840511
UniProt	O60503
Wiki	ADCY9

Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin.Like mouse Adcy9, the predicted human ADCY9 protein contains 12 transmembrane domains, Asn-linked glycosylation sites, and cAMP-dependent protein kinase phosphorylation sites; however, these proteins differ in the C2b domain due to a frameshift in the human ADCY9 coding sequence relative to the coding sequence of mouse Adcy9. Northern blot analysis detected 8.5- and 6.3-kb ADCY9 transcripts in all human tissues examined.

Reference

"Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9)."
Genomics 50:97-104(1998) [PubMed] [Europe PMC] [Abstract]

"An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation."
Pharmacogenetics 13:535-541(2003) [PubMed] [Europe PMC] [Abstract]

"Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways."
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Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

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Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

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J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]