Semaphorin 4D (SEMA4D)

CD100; A8; BB18; GR3; M-Sema G; M-Sema-G; SEMAJ; Coll-4; Sema Domain,Immunoglobulin Domain(Ig),Transmembrane Domain(TM)and Short Cytoplasmic Domain 4D

SPN	V404
HGNC	10732
MGI	109244
PubMed	14534257
RGD	1310554
UniProt	Q92854
Wiki	SEMA4D

CD100 was first identified as a cell surface protein of resting T cells; previous studies had shown that it was involved in lymphocyte activation. Hall et al. (1996) cloned CD100 from a cDNA library of phytohemagglutinin-activated human T cells. Sequence analysis showed that CD100 encodes an 863-amino acid polypeptide containing a secretory signal sequence, a single transmembrane domain, an immunoglobulin (Ig)-like domain, and a conserved 500-amino acid sema domain. Thus, Hall et al. (1996) stated that CD100 is a member of the semaphorin family and the first semaphorin believed to be involved in the immune system. See SEMA3F and SEMA3B. Northern blot analysis revealed that CD100 is expressed primarily as a 4.5-kb message in a variety of tissues, both hematopoietic and nonhematopoietic.

Reference

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Proc. Natl. Acad. Sci. U.S.A. 93:11780-11785(1996) [PubMed] [Europe PMC] [Abstract]

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Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates."
Cell 99:71-80(1999) [PubMed] [Europe PMC] [Abstract]

"Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway."
Mol. Cell. Biol. 25:6889-6898(2005) [PubMed] [Europe PMC] [Abstract]

"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]

"The semaphorin 4D-plexin-B signalling complex regulates dendritic and axonal complexity in developing neurons via diverse pathways."
Eur. J. Neurosci. 30:1193-1208(2009) [PubMed] [Europe PMC] [Abstract]

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

"The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D."
Nat. Struct. Biol. 10:843-848(2003) [PubMed] [Europe PMC] [Abstract]

"Structural basis of semaphorin-plexin signalling."
Nature 467:1118-1122(2010) [PubMed] [Europe PMC] [Abstract]