Integrin Alpha E (ITGaE)

CD103; ITG-AE; ITGA-E; Mucosal Lymphocyte Antigen 1; HML-1 antigen; Integrin alpha-IEL

SPN	V397
HGNC	6147
MGI	1298377
PubMed	19604725
UniProt	P38570
Wiki	ITGAE

Integrin, alpha E (ITGAE) is an integrin. CD103 binds integrin beta 7 (ITGB7) to form the complete heterodimeric integrin molecule alpha E beta 7, which has no distinct name. The alpha E beta7 complex is often referred to as "CD103" though this appelation strictly refers only to the alpha E chain. Note that the beta 7 subunit can bind with other integrin alpha; chains, such as alpha 4 (CD49d). Tregs are important for decreasing the immune response and appear to play a crucial role in the prevention of autoimmune diseases. Tregs are defined as CD4⁺/CD25⁺/Foxp3⁺ cells. Some CD4⁺/FoxP3^- cells also express CD103 and have been attributed regulatory activity. It is unclear whether the presence of CD103 on Treg cells represents a specialized feature for Treg, or Treg differentiation of IEL T cells.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV397Hu01	Recombinant Integrin Alpha E (ITGaE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV397Hu01	Monoclonal Antibody to Integrin Alpha E (ITGaE)	WB; IHC; ICC; IP.
Antibodies	PAV397Hu01	Polyclonal Antibody to Integrin Alpha E (ITGaE)	WB; IHC; ICC; IF.
Assay Kits	CLV397Hu01	CLIA Kit for Integrin Alpha E (ITGaE)	CLIA assay for Antigen Detection
Assay Kits	ELV397Hu01	ELISA Kit for Integrin Alpha E (ITGaE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV397Mu01	Recombinant Integrin Alpha E (ITGaE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV397Mu01	Monoclonal Antibody to Integrin Alpha E (ITGaE)	WB; IHC; ICC; IP.
Antibodies	PAV397Mu01	Polyclonal Antibody to Integrin Alpha E (ITGaE)	WB; IHC; ICC; IF.
Assay Kits	CLV397Mu01	CLIA Kit for Integrin Alpha E (ITGaE)	CLIA assay for Antigen Detection
Assay Kits	ELV397Mu01	ELISA Kit for Integrin Alpha E (ITGaE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV397Ra01	Recombinant Integrin Alpha E (ITGaE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV397Ra01	Monoclonal Antibody to Integrin Alpha E (ITGaE)	WB; IHC; ICC; IP.
Antibodies	PAV397Ra01	Polyclonal Antibody to Integrin Alpha E (ITGaE)	WB; IHC; ICC; IF.
Assay Kits	CLV397Ra01	CLIA Kit for Integrin Alpha E (ITGaE)	CLIA assay for Antigen Detection
Assay Kits	ELV397Ra01	ELISA Kit for Integrin Alpha E (ITGaE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV397Ca01	Recombinant Integrin Alpha E (ITGaE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV397Ca01	Monoclonal Antibody to Integrin Alpha E (ITGaE)	WB; IHC; ICC; IP.
Antibodies	PAV397Ca01	Polyclonal Antibody to Integrin Alpha E (ITGaE)	WB; IHC; ICC; IF.
Assay Kits	CLV397Ca01	CLIA Kit for Integrin Alpha E (ITGaE)	CLIA assay for Antigen Detection
Assay Kits	ELV397Ca01	ELISA Kit for Integrin Alpha E (ITGaE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV397Po01	Recombinant Integrin Alpha E (ITGaE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV397Po01	Monoclonal Antibody to Integrin Alpha E (ITGaE)	WB; IHC; ICC; IP.
Antibodies	PAV397Po01	Polyclonal Antibody to Integrin Alpha E (ITGaE)	WB; IHC; ICC; IF.
Assay Kits	CLV397Po01	CLIA Kit for Integrin Alpha E (ITGaE)	CLIA assay for Antigen Detection
Assay Kits	ELV397Po01	ELISA Kit for Integrin Alpha E (ITGaE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV397Bo01	Recombinant Integrin Alpha E (ITGaE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV397Bo01	Monoclonal Antibody to Integrin Alpha E (ITGaE)	WB; IHC; ICC; IP.
Antibodies	PAV397Bo01	Polyclonal Antibody to Integrin Alpha E (ITGaE)	WB; IHC; ICC; IF.
Assay Kits	CLV397Bo01	CLIA Kit for Integrin Alpha E (ITGaE)	CLIA assay for Antigen Detection
Assay Kits	ELV397Bo01	ELISA Kit for Integrin Alpha E (ITGaE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV397Rb01	Recombinant Integrin Alpha E (ITGaE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV397Rb01	Monoclonal Antibody to Integrin Alpha E (ITGaE)	WB; IHC; ICC; IP.
Antibodies	PAV397Rb01	Polyclonal Antibody to Integrin Alpha E (ITGaE)	WB; IHC; ICC; IF.
Assay Kits	CLV397Rb01	CLIA Kit for Integrin Alpha E (ITGaE)	CLIA assay for Antigen Detection
Assay Kits	ELV397Rb01	ELISA Kit for Integrin Alpha E (ITGaE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV397Mo01	Recombinant Integrin Alpha E (ITGaE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV397Mo01	Monoclonal Antibody to Integrin Alpha E (ITGaE)	WB; IHC; ICC; IP.
Antibodies	PAV397Mo01	Polyclonal Antibody to Integrin Alpha E (ITGaE)	WB; IHC; ICC; IF.
Assay Kits	CLV397Mo01	CLIA Kit for Integrin Alpha E (ITGaE)	CLIA assay for Antigen Detection
Assay Kits	ELV397Mo01	ELISA Kit for Integrin Alpha E (ITGaE)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution."
J. Biol. Chem. 269:6016-6025(1994) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion."
Genome Res. 10:165-173(2000) [PubMed] [Europe PMC] [Abstract]

"A family of beta 7 integrins on human mucosal lymphocytes."
Proc. Natl. Acad. Sci. U.S.A. 89:1924-1928(1992) [PubMed] [Europe PMC] [Abstract]

"The role of alpha and beta chains in ligand recognition by beta 7 integrins."
J. Biol. Chem. 275:25652-25664(2000) [PubMed] [Europe PMC] [Abstract]