Integrin Beta 4 (ITGb4)
CD104; ITG-B4; GP150
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the ITGB4) subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma.
Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV394Hu01 | Recombinant Integrin Beta 4 (ITGb4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV394Hu01 | Monoclonal Antibody to Integrin Beta 4 (ITGb4) | WB; IHC; ICC; IP. |
| PAV394Hu01 | Polyclonal Antibody to Integrin Beta 4 (ITGb4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV394Hu01 | CLIA Kit for Integrin Beta 4 (ITGb4) | CLIA assay for Antigen Detection |
| ELV394Hu01 | ELISA Kit for Integrin Beta 4 (ITGb4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV394Mu01 | Recombinant Integrin Beta 4 (ITGb4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV394Mu01 | Monoclonal Antibody to Integrin Beta 4 (ITGb4) | WB; IHC; ICC; IP. |
| PAV394Mu01 | Polyclonal Antibody to Integrin Beta 4 (ITGb4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV394Mu01 | CLIA Kit for Integrin Beta 4 (ITGb4) | CLIA assay for Antigen Detection |
| ELV394Mu01 | ELISA Kit for Integrin Beta 4 (ITGb4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV394Ra01 | Recombinant Integrin Beta 4 (ITGb4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV394Ra01 | Monoclonal Antibody to Integrin Beta 4 (ITGb4) | WB; IHC; ICC; IP. |
| PAV394Ra01 | Polyclonal Antibody to Integrin Beta 4 (ITGb4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV394Ra01 | CLIA Kit for Integrin Beta 4 (ITGb4) | CLIA assay for Antigen Detection |
| ELV394Ra01 | ELISA Kit for Integrin Beta 4 (ITGb4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV394Ca01 | Recombinant Integrin Beta 4 (ITGb4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV394Ca01 | Monoclonal Antibody to Integrin Beta 4 (ITGb4) | WB; IHC; ICC; IP. |
| PAV394Ca01 | Polyclonal Antibody to Integrin Beta 4 (ITGb4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV394Ca01 | CLIA Kit for Integrin Beta 4 (ITGb4) | CLIA assay for Antigen Detection |
| ELV394Ca01 | ELISA Kit for Integrin Beta 4 (ITGb4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV394Po01 | Recombinant Integrin Beta 4 (ITGb4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV394Po01 | Monoclonal Antibody to Integrin Beta 4 (ITGb4) | WB; IHC; ICC; IP. |
| PAV394Po01 | Polyclonal Antibody to Integrin Beta 4 (ITGb4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV394Po01 | CLIA Kit for Integrin Beta 4 (ITGb4) | CLIA assay for Antigen Detection |
| ELV394Po01 | ELISA Kit for Integrin Beta 4 (ITGb4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV394Bo01 | Recombinant Integrin Beta 4 (ITGb4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV394Bo01 | Monoclonal Antibody to Integrin Beta 4 (ITGb4) | WB; IHC; ICC; IP. |
| PAV394Bo01 | Polyclonal Antibody to Integrin Beta 4 (ITGb4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV394Bo01 | CLIA Kit for Integrin Beta 4 (ITGb4) | CLIA assay for Antigen Detection |
| ELV394Bo01 | ELISA Kit for Integrin Beta 4 (ITGb4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV394Rb01 | Recombinant Integrin Beta 4 (ITGb4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV394Rb01 | Monoclonal Antibody to Integrin Beta 4 (ITGb4) | WB; IHC; ICC; IP. |
| PAV394Rb01 | Polyclonal Antibody to Integrin Beta 4 (ITGb4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV394Rb01 | CLIA Kit for Integrin Beta 4 (ITGb4) | CLIA assay for Antigen Detection |
| ELV394Rb01 | ELISA Kit for Integrin Beta 4 (ITGb4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV394Mo01 | Recombinant Integrin Beta 4 (ITGb4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV394Mo01 | Monoclonal Antibody to Integrin Beta 4 (ITGb4) | WB; IHC; ICC; IP. |
| PAV394Mo01 | Polyclonal Antibody to Integrin Beta 4 (ITGb4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV394Mo01 | CLIA Kit for Integrin Beta 4 (ITGb4) | CLIA assay for Antigen Detection |
| ELV394Mo01 | ELISA Kit for Integrin Beta 4 (ITGb4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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"Genomic organization of the integrin beta 4 gene (ITGB4): a homozygous splice-site mutation in a patient with junctional epidermolysis bullosa associated with pyloric atresia."
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"The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome."
Mol. Biol. Cell 11:277-286(2000) [PubMed] [Europe PMC] [Abstract]
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Mol. Biol. Cell 20:2954-2962(2009) [PubMed] [Europe PMC] [Abstract]
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Cell. Mol. Life Sci. 69:2233-2244(2012) [PubMed] [Europe PMC] [Abstract]
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Submitted (APR-2008) to the PDB data bank
"Novel ITGB4 mutations in lethal and nonlethal variants of epidermolysis bullosa with pyloric atresia: missense versus nonsense."
Am. J. Hum. Genet. 63:1376-1387(1998) [PubMed] [Europe PMC] [Abstract]
"Epidermolysis bullosa with pyloric atresia: novel mutations in the beta-4 integrin gene (ITGB4)."
Am. J. Pathol. 152:157-166(1998) [PubMed] [Europe PMC] [Abstract]
"Compound heterozygosity for missense (L156P) and nonsense (R554X) mutations in the beta-4 integrin gene (ITGB4) underlies mild, nonlethal phenotype of epidermolysis bullosa with pyloric atresia."
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"A homozygous missense mutation in the cytoplasmic tail of beta4 integrin, G931D, that disrupts hemidesmosome assembly and underlies non-Herlitz junctional epidermolysis bullosa without pyloric atresia?"
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