Placental Protein 13 (PP13)

LGALS13; PLAC8; PP13; GAL13; Galectin 13; Galactoside-Binding Soluble Lectin 13; Placental tissue protein 13

SPN	V391
HGNC	15449
PubMed	23420029
UniProt	Q9UHV8
Wiki	LGALS13

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. Galactoside-binding soluble lectin 13 has lysophospholipase activity. It is composed of two identical subunits which are held together by disulfide bonds. This protein has structural similarity to several members of the beta-galactoside-binding S-type lectin family.By ultracentrifugation and SDS-PAGE, LGALS13 showed an apparent molecular mass of 29 to 30 kD.

Under reducing conditions, the apparent molecular mass was 16 kD, suggesting that LGALS13 is composed of 2 identical subunits held together by disulfide bonds. Western blot analysis and Ouchterlony gel diffusion were unable to detect LGALS13 in serum or in any other adult or fetal tissue examined.

Reference

"Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden crystal protein."
Placenta 20:703-710(1999) [PubMed] [Europe PMC] [Abstract]

"A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death."
Proc. Natl. Acad. Sci. U.S.A. 106:9731-9736(2009) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17)."
Oncodev. Biol. Med. 4:343-350(1983) [PubMed] [Europe PMC] [Abstract]

"Homology modelling and molecular dynamics studies of human placental tissue protein 13 (galectin-13)."
Protein Eng. 14:875-880(2001) [PubMed] [Europe PMC] [Abstract]