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Semaphorin 7A (SEMA7A)

CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH; SEMAK1; SEMAL; Semaphorin 7A,GPI Membrane Anchor; John Milton Hagen Blood Group; Semaphorin-K1; Semaphorin-L

SEMA7A is a membrane-bound semaphorin that associates with cell surfaces via a glycosylphosphatidylinositol (GPI) linkage. SEMA7A is also known as the John-Milton-Hagen (JMH) blood group antigen, an 80-kD glycoprotein expressed on activated lymphocytes and erythrocytes.

Czopik et al. (2006) found that T cells from immunized Sema7a -/- mice had increased proliferative responses to antigen that were not attributable to Sema7a deficiency on macrophages or dendritic cells. Sema7a -/- mice were prone to die at the onset of experimental autoimmune encephalomyelitis (EAE) and had higher clinical EAE scores compared with wildtype littermates. Delayed-type hypersensitivity responses were also enhanced in Sema7a -/- mice.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V386Hu01 Recombinant Semaphorin 7A (SEMA7A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Semaphorin 7A (SEMA7A) Bioactivity
Antibodies MV386Hu22 Monoclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IP.
PV386Hu01 Polyclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry;ICC/IF
Assay Kits KEV386Hu ELISA Kit for Semaphorin 7A (SEMA7A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Semaphorin 7A (SEMA7A) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V386Mu01 Recombinant Semaphorin 7A (SEMA7A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Semaphorin 7A (SEMA7A) Bioactivity
Antibodies NONE Monoclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IP.
PV386Mu01 Polyclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry;ICC/IF
Assay Kits KEV386Mu ELISA Kit for Semaphorin 7A (SEMA7A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Semaphorin 7A (SEMA7A) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Semaphorin 7A (SEMA7A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Semaphorin 7A (SEMA7A) Bioactivity
Antibodies NONE Monoclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Semaphorin 7A (SEMA7A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Semaphorin 7A (SEMA7A) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Semaphorin 7A (SEMA7A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Semaphorin 7A (SEMA7A) Bioactivity
Antibodies NONE Monoclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Semaphorin 7A (SEMA7A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Semaphorin 7A (SEMA7A) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Semaphorin 7A (SEMA7A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Semaphorin 7A (SEMA7A) Bioactivity
Antibodies NONE Monoclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Semaphorin 7A (SEMA7A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Semaphorin 7A (SEMA7A) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Semaphorin 7A (SEMA7A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Semaphorin 7A (SEMA7A) Bioactivity
Antibodies NONE Monoclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Semaphorin 7A (SEMA7A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Semaphorin 7A (SEMA7A) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Semaphorin 7A (SEMA7A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Semaphorin 7A (SEMA7A) Bioactivity
Antibodies NONE Monoclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Semaphorin 7A (SEMA7A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Semaphorin 7A (SEMA7A) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Semaphorin 7A (SEMA7A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Semaphorin 7A (SEMA7A) Bioactivity
Antibodies NONE Monoclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Semaphorin 7A (SEMA7A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Semaphorin 7A (SEMA7A) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Semaphorin 7A (SEMA7A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Semaphorin 7A (SEMA7A) Bioactivity
Antibodies NONE Monoclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Semaphorin 7A (SEMA7A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Semaphorin 7A (SEMA7A) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Semaphorin 7A (SEMA7A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Semaphorin 7A (SEMA7A) Bioactivity
Antibodies NONE Monoclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Semaphorin 7A (SEMA7A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Semaphorin 7A (SEMA7A) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Semaphorin 7A (SEMA7A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Semaphorin 7A (SEMA7A) Bioactivity
Antibodies NONE Monoclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Semaphorin 7A (SEMA7A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Semaphorin 7A (SEMA7A) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Semaphorin 7A (SEMA7A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Semaphorin 7A (SEMA7A) Bioactivity
Antibodies NONE Monoclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Semaphorin 7A (SEMA7A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Semaphorin 7A (SEMA7A) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Semaphorin 7A (SEMA7A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Semaphorin 7A (SEMA7A) Bioactivity
Antibodies NONE Monoclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Semaphorin 7A (SEMA7A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Semaphorin 7A (SEMA7A) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Semaphorin 7A (SEMA7A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Semaphorin 7A (SEMA7A) Bioactivity
Antibodies NONE Monoclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Semaphorin 7A (SEMA7A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Semaphorin 7A (SEMA7A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Semaphorin 7A (SEMA7A) CLIA assay for Antigen Detection

Reference

"New eukaryotic semaphorins with close homology to semaphorins of DNA viruses."
Genomics 51:340-350(1998) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108."
J. Immunol. 162:4094-4100(1999) [PubMed] [Europe PMC] [Abstract]

"Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins."
J. Biol. Chem. 273:22428-22434(1998) [PubMed] [Europe PMC] [Abstract]

"The molecular diversity of Sema7A, the semaphorin that carries the JMH blood group antigens."
Transfusion 47:133-146(2007) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules."
Immunobiology 200:234-245(1999) [PubMed] [Europe PMC] [Abstract]

"Semaphorin 7A promotes axon outgrowth through integrins and MAPKs."
Nature 424:398-405(2003) [PubMed] [Europe PMC] [Abstract]

"Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin."
Nature 446:680-684(2007) [PubMed] [Europe PMC] [Abstract]

"Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins."
J. Invest. Dermatol. 128:151-161(2008) [PubMed] [Europe PMC] [Abstract]

"Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1."
Cell 142:749-761(2010) [PubMed] [Europe PMC] [Abstract]

"A new SEMA7A variant found in Native Americans with alloantibody."
Vox Sang. 100:322-326(2011) [PubMed] [Europe PMC] [Abstract]