Relaxin/Insulin Like Family Peptide Receptor 1 (RXFP1)

RXFP1; RXFPR1; LGR7; LGR7.1; LGR7.10; LGR7.2; Relaxin receptor 1; Relaxin family peptide receptor 1; Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 7

SPN	V378
HGNC	19718
MGI	2682211
PubMed	21557732
RGD	1302973
UniProt	Q9HBX9
Wiki	RXFP1

• The deduced 757- and 723-amino acid LGR7 proteins are 33% identical to snail Lgr. They contain a low density lipoprotein receptor cysteine-rich motif, 10 LRRs, and 5 N-glycosylation sites in the N terminus; the 7-transmembrane region; and a unique C-terminal tail with a phosphorylation site. Northern blot analysis revealed expression of a 5.5-kb transcript in all rat tissues tested except spleen, and smaller transcripts were found in oviduct, uterus, colon, and brain. Expression of the long and short variants of LGR7 with mutations in transmembrane domain 6 (asp637 to tyr and asp603 to tyr, respectively), but not of wildtype LGR7, resulted in increased basal production of cAMP, as seen in similar experiments with the luteinizing hormone receptor (LHCGR) and the TSH receptor  but not the FSH receptor.

Reference

"The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7."
Mol. Endocrinol. 14:1257-1271(2000) [PubMed] [Europe PMC] [Abstract]

"Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity."
Mol. Hum. Reprod. 11:591-600(2005) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity."
Mol. Hum. Reprod. 7:799-809(2001) [PubMed] [Europe PMC] [Abstract]

"H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2."
J. Biol. Chem. 278:7855-7862(2003) [PubMed] [Europe PMC] [Abstract]

"Identification of the N-linked glycosylation sites of the human relaxin receptor and effect of glycosylation on receptor function."
Biochemistry 47:6953-6968(2008) [PubMed] [Europe PMC] [Abstract]

"The NMR solution structure of the relaxin (RXFP1) receptor lipoprotein receptor class A module and identification of key residues in the N-terminal region of the module that mediate receptor activation."
J. Biol. Chem. 282:4172-4184(2007) [PubMed] [Europe PMC] [Abstract]