Poliovirus Receptor Related Protein 1 (PVRL1)

CD111; HVEC; PRR1; CLPED1; ED4; HIgR; OFC7; PRR; PVRR1; SK12; Nectin 1; Herpesvirus Entry Mediator C; Herpesvirus Ig-like receptor

SPN	V364
HGNC	9706
MGI	1926483
PubMed	11559849
RGD	620791
UniProt	Q15223
Wiki	PVRL1

• PVRL1, or nectin-1, belongs to the nectin subfamily of immunoglobulin-like adhesion molecules that participate in Ca(2+)-independent cell-cell adhesion. Nectins bind to the actin cytoskeleton through the adaptor protein afadin (MLLT4) and are key components of adherens junctions (summary by Barron et al. (2008)).

• Members of the immunoglobin (Ig) superfamily have been shown to serve as receptors for various viruses. The human poliovirus receptor (PVR) is an integral membrane protein with one V-like extracellular Ig domain, 2 C-like extracellular Ig domains, a transmembrane region, and an intracytoplasmic region. Lopez et al. (1995) isolated a cDNA for a poliovirus receptor related gene, which they symbolized PRR.

Reference

"cDNA characterization and chromosomal localization of a gene related to the poliovirus receptor gene."
Gene 155:261-265(1995) [PubMed] [Europe PMC] [Abstract]

"Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor."
Science 280:1618-1620(1998) [PubMed] [Europe PMC] [Abstract]

"Novel, soluble isoform of the herpes simplex virus (HSV) receptor nectin1 (or prr1-HIgR-Hvec) modulates positively and negatively susceptibility to hsv infection."
J. Virol. 75:5684-5691(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia."
Nat. Genet. 25:427-430(2000) [PubMed] [Europe PMC] [Abstract]

"Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry."
J. Virol. 72:7064-7074(1998) [PubMed] [Europe PMC] [Abstract]

"Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein."
J. Cell Biol. 145:539-549(1999) [PubMed] [Europe PMC] [Abstract]

"Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction."
J. Biol. Chem. 276:43205-43215(2001) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Interaction of integrin alpha(v)beta3 with nectin. Implication in cross-talk between cell-matrix and cell-cell junctions."
J. Biol. Chem. 281:19631-19644(2006) [PubMed] [Europe PMC] [Abstract]

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion."
Nat. Commun. 2:577-577(2011) [PubMed] [Europe PMC] [Abstract]

"Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1."
PLoS Pathog. 7:E1002277-E1002277(2011) [PubMed] [Europe PMC] [Abstract]

"Nectin ectodomain structures reveal a canonical adhesive interface."
Nat. Struct. Mol. Biol. 19:906-915(2012) [PubMed] [Europe PMC] [Abstract]