Colony Stimulating Factor Receptor, Granulocyte (GCSFR)

CD114; G-CSFR; CSF3R; CSF3-R; GCSF-R

SPN	V358
HGNC	2439
MGI	1339755
PubMed	23136256
RGD	1309114
UniProt	Q99062
Wiki	GCSFR

The granulocyte colony-stimulating factor receptor (G-CSF-R) is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages. The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction.

Th G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. Mutations in the intracellular part of this receptor are associated with certain types of leukemia.

Reference

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