Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF)
HB-EGF; DTR; DTS; DTSF; HEGFL; Diphtheria Toxin Receptor; Proheparin-binding EGF-like growth factor; Diphtheria toxin receptor
Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function.
Diphtheria toxin inhibits protein synthesis in eukaryotic cells by catalyzing inactivation of elongation factor-2 (EF2). Entry of toxin into cells is dependent on binding to the cell surface.
Mice and rats are resistant to diphtheria toxin, and the resistance extends to cultured cells. Mouse-human hybrid cells are sensitive to diphtheria toxin. Creagan et al. (1975) showed that sensitivity is determined by human chromosome 5, which presumably carries a gene for a receptor for toxin.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV355Hu01 | Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV355Hu01 | Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | WB; IHC; ICC; IP. |
| PAV355Hu01 | Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV355Hu01 | CLIA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | CLIA assay for Antigen Detection |
| ELV355Hu01 | ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV355Mu01 | Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV355Mu01 | Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | WB; IHC; ICC; IP. |
| PAV355Mu01 | Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV355Mu01 | CLIA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | CLIA assay for Antigen Detection |
| ELV355Mu01 | ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV355Ra01 | Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV355Ra01 | Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | WB; IHC; ICC; IP. |
| PAV355Ra01 | Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV355Ra01 | CLIA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | CLIA assay for Antigen Detection |
| ELV355Ra01 | ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV355Ca01 | Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV355Ca01 | Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | WB; IHC; ICC; IP. |
| PAV355Ca01 | Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV355Ca01 | CLIA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | CLIA assay for Antigen Detection |
| ELV355Ca01 | ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV355Po01 | Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV355Po01 | Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | WB; IHC; ICC; IP. |
| PAV355Po01 | Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV355Po01 | CLIA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | CLIA assay for Antigen Detection |
| ELV355Po01 | ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV355Bo01 | Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV355Bo01 | Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | WB; IHC; ICC; IP. |
| PAV355Bo01 | Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV355Bo01 | CLIA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | CLIA assay for Antigen Detection |
| ELV355Bo01 | ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV355Rb01 | Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV355Rb01 | Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | WB; IHC; ICC; IP. |
| PAV355Rb01 | Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV355Rb01 | CLIA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | CLIA assay for Antigen Detection |
| ELV355Rb01 | ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV355Mo01 | Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV355Mo01 | Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | WB; IHC; ICC; IP. |
| PAV355Mo01 | Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV355Mo01 | CLIA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | CLIA assay for Antigen Detection |
| ELV355Mo01 | ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF."
Science 251:936-939(1991) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein."
J. Biol. Chem. 267:6205-6212(1992) [PubMed] [Europe PMC] [Abstract]
"Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity."
J. Biol. Chem. 270:1015-1019(1995) [PubMed] [Europe PMC] [Abstract]
"Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation."
EMBO J. 16:1268-1278(1997) [PubMed] [Europe PMC] [Abstract]
"ErbB and HB-EGF signaling in heart development and function."
Cell Struct. Funct. 31:1-14(2006) [PubMed] [Europe PMC] [Abstract]
"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor."
Mol. Cell 1:67-78(1997) [PubMed] [Europe PMC] [Abstract]