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Mannose Binding Lectin (MBL)

MBL2; COLEC1; HSMBPC; MBP1; MBP; Collectin-1; Mannose-binding protein C; Mannan Binding Protein; Mannose-Binding Lectin(Protein C)2,Soluble(Opsonic Defect)

Mannosebinding protein (MBP), initiates the lectin branch of the innate immune response by binding to the surface of potentially pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain. MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism.

It binds to sugars on the surface of bacterial, fungal and parasitic cells through C-terminal, Ca2 -dependent carbohydrate-recognition domains. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V354Hu01 Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Mannose Binding Lectin (MBL) Bioactivity
Antibodies MV354Hu22 Monoclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
PV354Hu01 Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IF.
LV354Hu71 Biotin Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry;ICC/IF
Assay Kits KEV354Hu ELISA Kit for Mannose Binding Lectin (MBL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Mannose Binding Lectin (MBL) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V354Mu01 Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Mannose Binding Lectin (MBL) Bioactivity
Antibodies NONE Monoclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
PV354Mu01 Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry;ICC/IF
Assay Kits KEV354Mu ELISA Kit for Mannose Binding Lectin (MBL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Mannose Binding Lectin (MBL) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V354Ra01 Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Mannose Binding Lectin (MBL) Bioactivity
Antibodies NONE Monoclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
PV354Ra01 Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Mannose Binding Lectin (MBL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Mannose Binding Lectin (MBL) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Mannose Binding Lectin (MBL) Bioactivity
Antibodies NONE Monoclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Mannose Binding Lectin (MBL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Mannose Binding Lectin (MBL) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Mannose Binding Lectin (MBL) Bioactivity
Antibodies NONE Monoclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Mannose Binding Lectin (MBL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Mannose Binding Lectin (MBL) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Mannose Binding Lectin (MBL) Bioactivity
Antibodies NONE Monoclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Mannose Binding Lectin (MBL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Mannose Binding Lectin (MBL) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Mannose Binding Lectin (MBL) Bioactivity
Antibodies NONE Monoclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Mannose Binding Lectin (MBL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Mannose Binding Lectin (MBL) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V354Ga01 Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Mannose Binding Lectin (MBL) Bioactivity
Antibodies MV354Ga21 Monoclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
PV354Ga01 Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Mannose Binding Lectin (MBL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Mannose Binding Lectin (MBL) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Mannose Binding Lectin (MBL) Bioactivity
Antibodies NONE Monoclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Mannose Binding Lectin (MBL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Mannose Binding Lectin (MBL) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Mannose Binding Lectin (MBL) Bioactivity
Antibodies NONE Monoclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Mannose Binding Lectin (MBL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Mannose Binding Lectin (MBL) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Mannose Binding Lectin (MBL) Bioactivity
Antibodies NONE Monoclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Mannose Binding Lectin (MBL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Mannose Binding Lectin (MBL) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Mannose Binding Lectin (MBL) Bioactivity
Antibodies NONE Monoclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Mannose Binding Lectin (MBL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Mannose Binding Lectin (MBL) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Mannose Binding Lectin (MBL) Bioactivity
Antibodies NONE Monoclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Mannose Binding Lectin (MBL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Mannose Binding Lectin (MBL) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Mannose Binding Lectin (MBL) Bioactivity
Antibodies NONE Monoclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Mannose Binding Lectin (MBL) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Mannose Binding Lectin (MBL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Mannose Binding Lectin (MBL) CLIA assay for Antigen Detection

Reference

"A human mannose-binding protein is an acute-phase reactant that shares sequence homology with other vertebrate lectins."
J. Exp. Med. 167:1034-1046(1988) [PubMed] [Europe PMC] [Abstract]

Erratum
J. Exp. Med. 174:753-753(1991)

"The human mannose-binding protein gene. Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10."
J. Exp. Med. 170:1175-1189(1989) [PubMed] [Europe PMC] [Abstract]

"Structure and evolutionary origin of the gene encoding a human serum mannose-binding protein."
Biochem. J. 262:763-771(1989) [PubMed] [Europe PMC] [Abstract]

"Different molecular events result in low protein levels of mannan-binding lectin in populations from South-East Africa and South America."
J. Immunol. 161:3169-3175(1998) [PubMed] [Europe PMC] [Abstract]

"Cloning and sequencing of mannan-binding lectin cDNA of Chinese."
Mian Yi Xue Za Zhi 15:83-86(1999)

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Restricted polymorphisms of the mannose-binding lectin gene in a population of Papua New Guinea."
Mutat. Res. 505:87-91(2002) [PubMed] [Europe PMC] [Abstract]

"Structure and function of mannan-binding proteins isolated from human liver and serum."
J. Biochem. 115:1148-1154(1994) [PubMed] [Europe PMC] [Abstract]

"A second serine protease associated with mannan-binding lectin that activates complement."
Nature 386:506-510(1997) [PubMed] [Europe PMC] [Abstract]

"Mannose-binding lectin engagement with late apoptotic and necrotic cells."
Eur. J. Immunol. 33:2853-2863(2003) [PubMed] [Europe PMC] [Abstract]

"Nucleic acid is a novel ligand for innate, immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin."
J. Biol. Chem. 279:32728-32736(2004) [PubMed] [Europe PMC] [Abstract]

"Mannan-binding protein blocks the activation of metalloproteases meprin alpha and beta."
J. Immunol. 175:3177-3185(2005) [PubMed] [Europe PMC] [Abstract]

"Comparative study of the human ficolins reveals unique features of Ficolin-3 (Hakata antigen)."
Mol. Immunol. 45:1623-1632(2008) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple alpha-helical coiled-coil."
Nat. Struct. Biol. 1:789-794(1994) [PubMed] [Europe PMC] [Abstract]

"Molecular basis of opsonic defect in immunodeficient children."
Lancet 337:1569-1570(1991) [PubMed] [Europe PMC] [Abstract]

"High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene."
Hum. Mol. Genet. 1:709-715(1992) [PubMed] [Europe PMC] [Abstract]

Erratum
Hum. Mol. Genet. 2:342-342(1993)

"Distinct and overlapping functions of allelic forms of human mannose binding protein."
Nat. Genet. 2:50-55(1992) [PubMed] [Europe PMC] [Abstract]

"Genotyping of the three major allelic variants of the human mannose-binding lectin gene by denaturing gradient gel electrophoresis."
Hum. Mutat. 14:80-83(1999) [PubMed] [Europe PMC] [Abstract]

"Mannose binding lectin genotypes influence recovery from hepatitis B virus infection."
J. Virol. 79:9192-9196(2005) [PubMed] [Europe PMC] [Abstract]

"Variant G57E of mannose binding lectin associated with protection against tuberculosis caused by Mycobacterium africanum but not by M. tuberculosis."
PLoS ONE 6:E20908-E20908(2011) [PubMed] [Europe PMC] [Abstract]