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Calreticulin (CRT)

CALR; RO; SSA; CC1qR; ERp60; HACBP; grp60; CRTC; CRP55; Calregulin; Sicca Syndrome Antigen A; Autoantigen Ro; Endoplasmic reticulum resident protein 60

Calreticulin is a protein that binds Ca2 ions (a second messenger molecule in signal transduction), rendering it inactive. The Ca2 is bound with low affinity, but high capacity, and can be released on a signal. Calreticulin is located in storage compartments associated with the endoplasmic reticulum.

Calreticulin is also known as calregulin, CRP55, CaBP3 and calsequestrin-like protein. The term "Mobilferrin" is considered to be the same as calreticulin by some sources.Calreticulin binds to misfolded proteins and prevents them from being exported from the Endoplasmic reticulum to the Golgi apparatus.A similar quality control chaperone, calnexin, performs the same service for soluble proteins as does calreticulin.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V348Hu01 Recombinant Calreticulin (CRT) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calreticulin (CRT) Bioactivity
Antibodies MV348Hu22 Monoclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IP.
PV348Hu01 Polyclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IF.
LV348Hu71 Biotin Linked-Polyclonal Antibody to Calreticulin (CRT) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calreticulin (CRT) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calreticulin (CRT) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry;ICC/IF
Assay Kits KEV348Hu ELISA Kit for Calreticulin (CRT) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calreticulin (CRT) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V348Mu01 Recombinant Calreticulin (CRT) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calreticulin (CRT) Bioactivity
Antibodies NONE Monoclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IP.
PV348Mu01 Polyclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calreticulin (CRT) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calreticulin (CRT) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calreticulin (CRT) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry;ICC/IF
Assay Kits KEV348Mu ELISA Kit for Calreticulin (CRT) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calreticulin (CRT) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V348Ra01 Recombinant Calreticulin (CRT) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calreticulin (CRT) Bioactivity
Antibodies MV348Ra21 Monoclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IP.
PV348Ra01 Polyclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calreticulin (CRT) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calreticulin (CRT) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calreticulin (CRT) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry;ICC/IF
Assay Kits KEV348Ra ELISA Kit for Calreticulin (CRT) Enzyme-linked immunosorbent assay for Antigen Detection
KCV348Ra CLIA kit for Calreticulin (CRT) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calreticulin (CRT) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calreticulin (CRT) Bioactivity
Antibodies NONE Monoclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calreticulin (CRT) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calreticulin (CRT) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calreticulin (CRT) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calreticulin (CRT) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calreticulin (CRT) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calreticulin (CRT) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calreticulin (CRT) Bioactivity
Antibodies NONE Monoclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calreticulin (CRT) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calreticulin (CRT) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calreticulin (CRT) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calreticulin (CRT) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calreticulin (CRT) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calreticulin (CRT) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calreticulin (CRT) Bioactivity
Antibodies NONE Monoclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calreticulin (CRT) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calreticulin (CRT) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calreticulin (CRT) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calreticulin (CRT) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calreticulin (CRT) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calreticulin (CRT) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calreticulin (CRT) Bioactivity
Antibodies NONE Monoclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calreticulin (CRT) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calreticulin (CRT) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calreticulin (CRT) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calreticulin (CRT) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calreticulin (CRT) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calreticulin (CRT) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calreticulin (CRT) Bioactivity
Antibodies NONE Monoclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calreticulin (CRT) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calreticulin (CRT) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calreticulin (CRT) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calreticulin (CRT) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calreticulin (CRT) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calreticulin (CRT) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calreticulin (CRT) Bioactivity
Antibodies NONE Monoclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calreticulin (CRT) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calreticulin (CRT) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calreticulin (CRT) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calreticulin (CRT) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calreticulin (CRT) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calreticulin (CRT) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calreticulin (CRT) Bioactivity
Antibodies NONE Monoclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calreticulin (CRT) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calreticulin (CRT) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calreticulin (CRT) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calreticulin (CRT) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calreticulin (CRT) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calreticulin (CRT) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calreticulin (CRT) Bioactivity
Antibodies NONE Monoclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calreticulin (CRT) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calreticulin (CRT) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calreticulin (CRT) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calreticulin (CRT) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calreticulin (CRT) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calreticulin (CRT) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calreticulin (CRT) Bioactivity
Antibodies NONE Monoclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calreticulin (CRT) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calreticulin (CRT) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calreticulin (CRT) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calreticulin (CRT) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calreticulin (CRT) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calreticulin (CRT) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calreticulin (CRT) Bioactivity
Antibodies NONE Monoclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calreticulin (CRT) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calreticulin (CRT) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calreticulin (CRT) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calreticulin (CRT) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calreticulin (CRT) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calreticulin (CRT) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calreticulin (CRT) Bioactivity
Antibodies NONE Monoclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calreticulin (CRT) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calreticulin (CRT) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calreticulin (CRT) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calreticulin (CRT) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calreticulin (CRT) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calreticulin (CRT) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calreticulin (CRT) CLIA assay for Antigen Detection

Reference

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"In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin alpha subunits."
Biochemistry 30:9859-9866(1991) [PubMed] [Europe PMC] [Abstract]

"Sequence similarity of calreticulin with a Ca2(+)-binding protein that co-purifies with an Ins(1,4,5)P3-sensitive Ca2+ store in HL-60 cells."
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"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
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"The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes."
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"A two-dimensional gel database of human colon carcinoma proteins."
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"Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen."
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"Calreticulin is expressed on the cell surface of activated human peripheral blood T lymphocytes in association with major histocompatibility complex class I molecules."
J. Biol. Chem. 274:16917-16922(1999) [PubMed] [Europe PMC] [Abstract]

"Calreticulin is a receptor for nuclear export."
J. Cell Biol. 152:127-140(2001) [PubMed] [Europe PMC] [Abstract]

"Human placental calreticulin characterization of domain structure and post-translational modifications."
Eur. J. Biochem. 268:2558-2565(2001) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain."
J. Biol. Chem. 285:35551-35557(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Resveratrol-induced changes of the human adipocyte secretion profile."
J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structural framework of the GABARAP-calreticulin interface --implications for substrate binding to endoplasmic reticulum chaperones."
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"X-ray structure of the human calreticulin globular domain reveals a peptide-binding area and suggests a multi-molecular mechanism."
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