Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4)
EPVH; PAR14; PAR17; Parvulin; Eukaryotic Parvulin Homologue ; Parvulin-14; Parvulin-17; Peptidyl-prolyl cis/trans isomerase EPVH
Sequence analysis predicted that the 131-amino acid PIN4 protein contains a PPIase domain preceded by a 40-amino acid glycine- and lysine-rich N-terminal sequence.
PIN4, however, lacks a WW domain, a nuclear localization motif, and residues required for phosphoprotein interactions. Multiple-tissue Northern blot analysis detected variable expression of an approximately 1.0-kb PIN4 transcript in all tissues tested, with notably lower expression in neuronal tissue. Transmission electron microscopy demonstrated preferential localization of PIN4 in the mitochondrial matrix. Functional analysis failed to show PPIase activity, possibly due to proteolytic degradation or different substrate requirements.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV344Hu01 | Recombinant Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV344Hu01 | Monoclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | WB; IHC; ICC; IP. |
| PAV344Hu01 | Polyclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV344Hu01 | CLIA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | CLIA assay for Antigen Detection |
| ELV344Hu01 | ELISA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV344Mu01 | Recombinant Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV344Mu01 | Monoclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | WB; IHC; ICC; IP. |
| PAV344Mu01 | Polyclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV344Mu01 | CLIA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | CLIA assay for Antigen Detection |
| ELV344Mu01 | ELISA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV344Ra01 | Recombinant Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV344Ra01 | Monoclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | WB; IHC; ICC; IP. |
| PAV344Ra01 | Polyclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV344Ra01 | CLIA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | CLIA assay for Antigen Detection |
| ELV344Ra01 | ELISA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV344Ca01 | Recombinant Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV344Ca01 | Monoclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | WB; IHC; ICC; IP. |
| PAV344Ca01 | Polyclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV344Ca01 | CLIA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | CLIA assay for Antigen Detection |
| ELV344Ca01 | ELISA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV344Po01 | Recombinant Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV344Po01 | Monoclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | WB; IHC; ICC; IP. |
| PAV344Po01 | Polyclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV344Po01 | CLIA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | CLIA assay for Antigen Detection |
| ELV344Po01 | ELISA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV344Bo01 | Recombinant Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV344Bo01 | Monoclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | WB; IHC; ICC; IP. |
| PAV344Bo01 | Polyclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV344Bo01 | CLIA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | CLIA assay for Antigen Detection |
| ELV344Bo01 | ELISA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV344Rb01 | Recombinant Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV344Rb01 | Monoclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | WB; IHC; ICC; IP. |
| PAV344Rb01 | Polyclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV344Rb01 | CLIA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | CLIA assay for Antigen Detection |
| ELV344Rb01 | ELISA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV344Mo01 | Recombinant Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV344Mo01 | Monoclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | WB; IHC; ICC; IP. |
| PAV344Mo01 | Polyclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV344Mo01 | CLIA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | CLIA assay for Antigen Detection |
| ELV344Mo01 | ELISA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 4 (PIN4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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BMC Biol. 5:37-37(2007) [PubMed] [Europe PMC] [Abstract]
"Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14."
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BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"NMR solution structure of hPar14 reveals similarity to the peptidyl prolyl cis/trans isomerase domain of the mitotic regulator hPin1 but indicates a different functionality of the protein."
J. Mol. Biol. 301:1003-1017(2000) [PubMed] [Europe PMC] [Abstract]
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