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Sorbitol Dehydrogenase (SDH)

SORD; L-iditol 2-dehydrogenase

Sorbitol dehydrogenase is an enzyme in carbohydrate metabolism converting sorbitol, the sugar alcohol form of glucose, into fructose. Together with aldose reductase, it provides a way for the body to produce fructose from glucose without using ATP. Sorbitol dehydrogenase uses NAD+ as a cofactor; its reaction is sorbitol + NAD+ + H+ --> fructose + NADH. A zinc ion is also involved in catalysis. Organs that use it most frequently include the liver and seminal vesicle; it is found in all kinds of organisms from bacteria to humans. A secondary use is the metabolism of dietary sorbitol, though sorbitol is known not to absorb as well in the intestine as its related compounds glucose and fructose, and is usually found in quite small amounts in the diet anyway (except when used as an artificial sweetener).

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV339Hu01 Recombinant Sorbitol Dehydrogenase (SDH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV339Hu01 Monoclonal Antibody to Sorbitol Dehydrogenase (SDH) WB; IHC; ICC; IP.
PAV339Hu01 Polyclonal Antibody to Sorbitol Dehydrogenase (SDH) WB; IHC; ICC; IF.
Assay Kits CLV339Hu01 CLIA Kit for Sorbitol Dehydrogenase (SDH) CLIA assay for Antigen Detection
ELV339Hu01 ELISA Kit for Sorbitol Dehydrogenase (SDH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV339Mu01 Recombinant Sorbitol Dehydrogenase (SDH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV339Mu01 Monoclonal Antibody to Sorbitol Dehydrogenase (SDH) WB; IHC; ICC; IP.
PAV339Mu01 Polyclonal Antibody to Sorbitol Dehydrogenase (SDH) WB; IHC; ICC; IF.
Assay Kits CLV339Mu01 CLIA Kit for Sorbitol Dehydrogenase (SDH) CLIA assay for Antigen Detection
ELV339Mu01 ELISA Kit for Sorbitol Dehydrogenase (SDH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV339Ra01 Recombinant Sorbitol Dehydrogenase (SDH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV339Ra01 Monoclonal Antibody to Sorbitol Dehydrogenase (SDH) WB; IHC; ICC; IP.
PAV339Ra01 Polyclonal Antibody to Sorbitol Dehydrogenase (SDH) WB; IHC; ICC; IF.
Assay Kits CLV339Ra01 CLIA Kit for Sorbitol Dehydrogenase (SDH) CLIA assay for Antigen Detection
ELV339Ra01 ELISA Kit for Sorbitol Dehydrogenase (SDH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV339Ca01 Recombinant Sorbitol Dehydrogenase (SDH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV339Ca01 Monoclonal Antibody to Sorbitol Dehydrogenase (SDH) WB; IHC; ICC; IP.
PAV339Ca01 Polyclonal Antibody to Sorbitol Dehydrogenase (SDH) WB; IHC; ICC; IF.
Assay Kits CLV339Ca01 CLIA Kit for Sorbitol Dehydrogenase (SDH) CLIA assay for Antigen Detection
ELV339Ca01 ELISA Kit for Sorbitol Dehydrogenase (SDH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV339Po01 Recombinant Sorbitol Dehydrogenase (SDH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV339Po01 Monoclonal Antibody to Sorbitol Dehydrogenase (SDH) WB; IHC; ICC; IP.
PAV339Po01 Polyclonal Antibody to Sorbitol Dehydrogenase (SDH) WB; IHC; ICC; IF.
Assay Kits CLV339Po01 CLIA Kit for Sorbitol Dehydrogenase (SDH) CLIA assay for Antigen Detection
ELV339Po01 ELISA Kit for Sorbitol Dehydrogenase (SDH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV339Bo01 Recombinant Sorbitol Dehydrogenase (SDH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV339Bo01 Monoclonal Antibody to Sorbitol Dehydrogenase (SDH) WB; IHC; ICC; IP.
PAV339Bo01 Polyclonal Antibody to Sorbitol Dehydrogenase (SDH) WB; IHC; ICC; IF.
Assay Kits CLV339Bo01 CLIA Kit for Sorbitol Dehydrogenase (SDH) CLIA assay for Antigen Detection
ELV339Bo01 ELISA Kit for Sorbitol Dehydrogenase (SDH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV339Rb01 Recombinant Sorbitol Dehydrogenase (SDH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV339Rb01 Monoclonal Antibody to Sorbitol Dehydrogenase (SDH) WB; IHC; ICC; IP.
PAV339Rb01 Polyclonal Antibody to Sorbitol Dehydrogenase (SDH) WB; IHC; ICC; IF.
Assay Kits CLV339Rb01 CLIA Kit for Sorbitol Dehydrogenase (SDH) CLIA assay for Antigen Detection
ELV339Rb01 ELISA Kit for Sorbitol Dehydrogenase (SDH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV339Mo01 Recombinant Sorbitol Dehydrogenase (SDH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV339Mo01 Monoclonal Antibody to Sorbitol Dehydrogenase (SDH) WB; IHC; ICC; IP.
PAV339Mo01 Polyclonal Antibody to Sorbitol Dehydrogenase (SDH) WB; IHC; ICC; IF.
Assay Kits CLV339Mo01 CLIA Kit for Sorbitol Dehydrogenase (SDH) CLIA assay for Antigen Detection
ELV339Mo01 ELISA Kit for Sorbitol Dehydrogenase (SDH) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The human sorbitol dehydrogenase gene: cDNA cloning, sequence determination, and mapping by fluorescence in situ hybridization."
Genomics 21:354-358(1994) [PubMed] [Europe PMC] [Abstract]

"Structural organization of the human sorbitol dehydrogenase gene (SORD)."
Genomics 26:55-62(1995) [PubMed] [Europe PMC] [Abstract]

"Identification and characterisation of a sequence related to human sorbitol dehydrogenase."
Eur. J. Biochem. 245:760-767(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Variability within mammalian sorbitol dehydrogenases. The primary structure of the human liver enzyme."
Eur. J. Biochem. 186:543-550(1989) [PubMed] [Europe PMC] [Abstract]

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

"Polyol pathway in human epididymis and semen."
J. Androl. 27:233-239(2006) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Sorbitol dehydrogenase expression is regulated by androgens in the human prostate."
Oncol. Rep. 23:1233-1239(2010) [PubMed] [Europe PMC] [Abstract]

"ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cells."
J. Biol. Chem. 284:19974-19981(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase."
Structure 11:1071-1085(2003) [PubMed] [Europe PMC] [Abstract]