Protein Disulfide Isomerase A3 (PDIA3)

P58; ERp61; ERp57; ERp60; GRP57; PI-PLC; GRP58; Glucose Regulated Protein,58kDa; Protein Disulfide Isomerase-Associated 3; Endoplasmic reticulum resident protein 57

SPN	V337
HGNC	4606
MGI	95834
PubMed	20843786
RGD	68430
UniProt	P30101
Wiki	PDIA3

The PDIA3 protein has protein disulfide isomerase activity. PDIA3 is also part of the major histocompatibility complex (MHC) class I peptide-loading complex (TAP1), which is essential for formation of the final antigen conformation and export from the endoplasmic reticulum to the cell surface.

The cDNA encoding human GRP58 was cloned independently by Bourdi et al. (1995), Koivunen et al. (1996), and Hirano et al. (1995). All reported that the gene encodes a 505-amino acid polypeptide with significant homology to human protein disulfide isomerase (PDI). Bourdi et al. (1995) noted that the sequence includes a putative nuclear localization motif and an endoplasmic reticulum (ER)-retention/retrieval motif.

Reference

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, Submitted (DEC-2008) to UniProtKB

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"The solution structure of the second thioredoxin domain of human protein disulfide-isomerase A3."
Submitted (OCT-2006) to the PDB data bank

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