Killer Cell Immunoglobulin Like Receptor 2DL1 (KIR2DL1)

CD158A; Cl-42; NKAT1; Killer Cell Immunoglobulin Like Receptor Two Domains, Long Cytoplasmic Tail,1; Natural killer-associated transcript 1; MHC class I NK cell receptor

SPN	V325
HGNC	6329
PubMed	24043749
UniProt	P43626
Wiki	KIR2DL1

The existence of human inhibitory natural killer (NK) cell receptors for MHC class I molecules (now designated killer cell Ig-like receptors, or KIRs), was inferred from the observation that NK cells killed HLA class I-deficient cell lines. Colonna and Samaridis (1995) obtained cDNA for a killer cell immunoglobulin-like receptor (KIR2DL1), which they termed NKAT1, encoding a deduced 348-amino acid type I transmembrane protein. Sequence analysis revealed a 21-amino acid signal peptide, an extracellular region containing two C2-type Ig-like domains with 5 potential N-linked glycosylation sites, a 19-amino acid hydrophobic transmembrane region, and an 84-amino acid long cytoplasmic domain. Southern blot analysis of genomic DNA showed several hybridizing bands suggestive of a family of genes closely related to NKAT1.

Reference

"Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells."
Science 268:405-408(1995) [PubMed] [Europe PMC] [Abstract]

"Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains."
Immunity 2:439-449(1995) [PubMed] [Europe PMC] [Abstract]

"Human diversity in killer cell inhibitory receptor genes."
Immunity 7:753-763(1997) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells."
Nat. Immunol. 9:898-907(2008) [PubMed] [Europe PMC] [Abstract]

"Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors."
Nature 389:96-100(1997) [PubMed] [Europe PMC] [Abstract]