Interleukin 5 Receptor Alpha (IL5Ra)

CDw125; CD125; IL5R-A; IL5-RA; HSIL5R3; IL5R; IL5R-A

SPN	V324
HGNC	6017
MGI	96558
PubMed	18256354
RGD	70938
UniProt	Q01344
Wiki	IL5RA

Interleukin 5 receptor, alpha (IL5RA) is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported.

Reference

"A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF."
Cell 66:1175-1184(1991) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and expression of the human interleukin 5 receptor."
J. Exp. Med. 175:341-351(1992) [PubMed] [Europe PMC] [Abstract]

"Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit."
Proc. Natl. Acad. Sci. U.S.A. 89:7041-7045(1992) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm."
Structure 11:845-853(2003) [PubMed] [Europe PMC] [Abstract]

"Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5Ralpha."
Structure 19:1864-1875(2011) [PubMed] [Europe PMC] [Abstract]