Granulysin (GNLY)
NKG5; LAG-2; TLA519; T-Lymphocyte Activation Gene 519
Granulysin is a protein present in cytotoxic granules of cytotoxic T cells and natural killer cells. Granulysin is a member of the saposin-like protein (SAPLIP) family and is released from cytotoxic T cells upon antigen stimulation. Granulysin has antimicrobial activity against M. tuberculosis and other organisms.
Granulysin is alternatively spliced, resulting in the NKG5 and 519 transcripts.Granulysin is a cytolytic and proinflammatory molecule first identified by a screen for genes expressed “late”(3-5 days) after activation of human peripheral blood mononuclear cells.Granulysin is present in cytolytic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granulysin is made as a 15 kD molecule, and a portion of it is cleaved at both the amino and carboxy termini into a 9 kD form.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV317Hu01 | Recombinant Granulysin (GNLY) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV317Hu01 | Monoclonal Antibody to Granulysin (GNLY) | WB; IHC; ICC; IP. |
| PAV317Hu01 | Polyclonal Antibody to Granulysin (GNLY) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV317Hu01 | CLIA Kit for Granulysin (GNLY) | CLIA assay for Antigen Detection |
| ELV317Hu01 | ELISA Kit for Granulysin (GNLY) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV317Mu01 | Recombinant Granulysin (GNLY) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV317Mu01 | Monoclonal Antibody to Granulysin (GNLY) | WB; IHC; ICC; IP. |
| PAV317Mu01 | Polyclonal Antibody to Granulysin (GNLY) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV317Mu01 | CLIA Kit for Granulysin (GNLY) | CLIA assay for Antigen Detection |
| ELV317Mu01 | ELISA Kit for Granulysin (GNLY) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV317Ra01 | Recombinant Granulysin (GNLY) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV317Ra01 | Monoclonal Antibody to Granulysin (GNLY) | WB; IHC; ICC; IP. |
| PAV317Ra01 | Polyclonal Antibody to Granulysin (GNLY) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV317Ra01 | CLIA Kit for Granulysin (GNLY) | CLIA assay for Antigen Detection |
| ELV317Ra01 | ELISA Kit for Granulysin (GNLY) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV317Ca01 | Recombinant Granulysin (GNLY) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV317Ca01 | Monoclonal Antibody to Granulysin (GNLY) | WB; IHC; ICC; IP. |
| PAV317Ca01 | Polyclonal Antibody to Granulysin (GNLY) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV317Ca01 | CLIA Kit for Granulysin (GNLY) | CLIA assay for Antigen Detection |
| ELV317Ca01 | ELISA Kit for Granulysin (GNLY) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV317Po01 | Recombinant Granulysin (GNLY) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV317Po01 | Monoclonal Antibody to Granulysin (GNLY) | WB; IHC; ICC; IP. |
| PAV317Po01 | Polyclonal Antibody to Granulysin (GNLY) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV317Po01 | CLIA Kit for Granulysin (GNLY) | CLIA assay for Antigen Detection |
| ELV317Po01 | ELISA Kit for Granulysin (GNLY) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV317Bo01 | Recombinant Granulysin (GNLY) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV317Bo01 | Monoclonal Antibody to Granulysin (GNLY) | WB; IHC; ICC; IP. |
| PAV317Bo01 | Polyclonal Antibody to Granulysin (GNLY) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV317Bo01 | CLIA Kit for Granulysin (GNLY) | CLIA assay for Antigen Detection |
| ELV317Bo01 | ELISA Kit for Granulysin (GNLY) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV317Rb01 | Recombinant Granulysin (GNLY) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV317Rb01 | Monoclonal Antibody to Granulysin (GNLY) | WB; IHC; ICC; IP. |
| PAV317Rb01 | Polyclonal Antibody to Granulysin (GNLY) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV317Rb01 | CLIA Kit for Granulysin (GNLY) | CLIA assay for Antigen Detection |
| ELV317Rb01 | ELISA Kit for Granulysin (GNLY) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV317Mo01 | Recombinant Granulysin (GNLY) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV317Mo01 | Monoclonal Antibody to Granulysin (GNLY) | WB; IHC; ICC; IP. |
| PAV317Mo01 | Polyclonal Antibody to Granulysin (GNLY) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV317Mo01 | CLIA Kit for Granulysin (GNLY) | CLIA assay for Antigen Detection |
| ELV317Mo01 | ELISA Kit for Granulysin (GNLY) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The isolation and sequence of a novel gene from a human functional T cell line."
J. Exp. Med. 165:601-614(1987) [PubMed] [Europe PMC] [Abstract]
"A cDNA clone expressed in natural killer and T cells that likely encodes a secreted protein."
J. Exp. Med. 172:1159-1163(1990) [PubMed] [Europe PMC] [Abstract]
"Genomic structure of NKG5, a human NK and T cell-specific activation gene."
Immunogenetics 37:102-107(1993) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells."
Biochem. Pharmacol. 59:317-320(2000) [PubMed] [Europe PMC] [Abstract]
"An antimicrobial activity of cytolytic T cells mediated by granulysin."
Science 282:121-125(1998) [PubMed] [Europe PMC] [Abstract]
"Biosynthesis of granulysin, a novel cytolytic molecule."
Mol. Immunol. 36:413-422(1999) [PubMed] [Europe PMC] [Abstract]
"Granulysin crystal structure and a structure-derived lytic mechanism."
J. Mol. Biol. 325:355-365(2003) [PubMed] [Europe PMC] [Abstract]