Interleukin 1 Receptor Associated Kinase 4 (IRAK4)
NY-REN-64
IRAK-4 is a protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors.Animals without IRAK-4 are more susceptible to viruses and bacteria but completely resistant to LPS challenge.Unlike the other IRAK proteins, however, but similar to Pelle, IRAK4 has a short C-terminal domain. Northern blot analysis revealed expression of 3.0- and 4.4-kb transcripts, with strongest expression in kidney and liver. Luciferase reporter analysis showed that IRAK4 lacking the kinase domain inhibited IL1- but not tumor necrosis factor (TNF)- induced NFKB and IRAK1 activation. SDS-PAGE and autoradiographic analysis indicated that IRAK4 phosphorylates and activates IRAK1 at thr387, but not vice versa.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | V316Hu01 | Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Bioactivity | |
| Antibodies | MV316Hu22 | Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IP. |
| PV316Hu01 | Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEV316Hu | ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | V316Ra01 | Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Bioactivity | |
| Antibodies | MV316Ra21 | Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IP. |
| PV316Ra01 | Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEV316Ra | ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) | CLIA assay for Antigen Detection |
Reference
"IRAK4: a novel member of the IRAK family with the properties of an IRAK-kinase."
Proc. Natl. Acad. Sci. U.S.A. 99:5567-5572(2002) [PubMed] [Europe PMC] [Abstract]
"Antigens recognized by autologous antibody in patients with renal-cell carcinoma."
Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex."
J. Biol. Chem. 278:10952-10956(2003) [PubMed] [Europe PMC] [Abstract]
"Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4."
J. Exp. Med. 197:263-268(2003) [PubMed] [Europe PMC] [Abstract]
"Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections."
J. Exp. Med. 198:521-531(2003) [PubMed] [Europe PMC] [Abstract]
"IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness."
J. Biol. Chem. 279:26748-26753(2004) [PubMed] [Europe PMC] [Abstract]
"Pyogenic bacterial infections in humans with IRAK-4 deficiency."
Science 299:2076-2079(2003) [PubMed] [Europe PMC] [Abstract]
"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines."
Immunity 23:479-490(2005) [PubMed] [Europe PMC] [Abstract]
"Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1."
Nat. Immunol. 7:1057-1065(2006) [PubMed] [Europe PMC] [Abstract]
"Cross-talk between IRAK-4 and the NADPH oxidase."
Biochem. J. 403:451-461(2007) [PubMed] [Europe PMC] [Abstract]
"IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression."
J. Biol. Chem. 282:13552-13560(2007) [PubMed] [Europe PMC] [Abstract]
"IRAK4 and NEMO mutations in otherwise healthy children with recurrent invasive pneumococcal disease."
J. Med. Genet. 44:16-23(2007) [PubMed] [Europe PMC] [Abstract]
"The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1."
Biochem. J. 409:43-52(2008) [PubMed] [Europe PMC] [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
"IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal)."
J. Biol. Chem. 285:18276-18282(2010) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Natural loss-of-function mutation of myeloid differentiation protein 88 disrupts its ability to form Myddosomes."
J. Biol. Chem. 286:11875-11882(2011) [PubMed] [Europe PMC] [Abstract]
"What the Myddosome structure tells us about the initiation of innate immunity."
Trends Immunol. 32:104-109(2011) [PubMed] [Europe PMC] [Abstract]
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
"Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper."
Structure 14:1835-1844(2006) [PubMed] [Europe PMC] [Abstract]
"Crystal structures of the apo and inhibited IRAK4 kinase domain."
Submitted (DEC-2006) to the PDB data bank
"Cutting Edge: IL-1 receptor-associated kinase 4 structures reveal novel features and multiple conformations."
J. Immunol. 178:2641-2645(2007) [PubMed] [Europe PMC] [Abstract]
"Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling."
Nature 465:885-890(2010) [PubMed] [Europe PMC] [Abstract]
"TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway."
J. Immunol. 179:4754-4765(2007) [PubMed] [Europe PMC] [Abstract]
"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
"Impaired neutrophil migration and phagocytosis in IRAK-4 deficiency."
Br. J. Haematol. 147:153-156(2009) [PubMed] [Europe PMC] [Abstract]
"Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency."
Medicine (Baltimore) 89:403-425(2010) [PubMed] [Europe PMC] [Abstract]
"Functional assessment of the mutational effects of human IRAK4 and MyD88 genes."
Mol. Immunol. 58:66-76(2014) [PubMed] [Europe PMC] [Abstract]