Macrophage Stimulating 1 Receptor (MST1R)

CD136; CDw136; MST1-R; PTK8; RON; C-Met-Related Tyrosine Kinase; PTK8 Protein Tyrosine Kinase 8; Macrophage-stimulating protein receptor

SPN	V309
HGNC	7381
MGI	99614
PubMed	21543897
RGD	1306465
UniProt	Q04912
Wiki	MST1R

Ronsin et al. (1993) cloned a member of the MET receptor family, which they designated RON, from a human foreskin keratinocyte cDNA library. Comparison with MET, the hepatocyte growth factor receptor, suggested that the RON gene product is also a membrane-spanning disulfide-linked heterodimer with intracellular tyrosine kinase activity.

Gaudino et al. (1994) showed that the RON gene is expressed at the cell surface of several epithelial cell types in addition to granulocytes and monocytes. They found that The RON mRNA is translated into a glycosylated precursor that is cleaved into a 185-kD heterodimer of 35-kD (alpha) and 150-kD (beta) subunits joined by the predicted disulfide linkage.

Reference

"A novel putative receptor protein tyrosine kinase of the met family."
Oncogene 8:1195-1202(1993) [PubMed] [Europe PMC] [Abstract]

"A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype."
Mol. Cell. Biol. 16:5518-5526(1996) [PubMed] [Europe PMC] [Abstract]

"Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis."
Arthritis Res. Ther. 10:R73-R73(2008) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor."
Mol. Cell. Biol. 13:4600-4608(1993) [PubMed] [Europe PMC] [Abstract]

"RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP."
EMBO J. 13:3524-3532(1994) [PubMed] [Europe PMC] [Abstract]

"Identification of the ron gene product as the receptor for the human macrophage stimulating protein."
Science 266:117-119(1994) [PubMed] [Europe PMC] [Abstract]

"Proteolytic cleavage and activation of pro-macrophage-stimulating protein and upregulation of its receptor in tissue injury."
J. Invest. Dermatol. 111:573-581(1998) [PubMed] [Europe PMC] [Abstract]

"Macrophage stimulating protein-induced epithelial cell adhesion is mediated by a PI3-K-dependent, but FAK-independent mechanism."
Exp. Cell Res. 248:575-582(1999) [PubMed] [Europe PMC] [Abstract]

"Interaction of macrophage-stimulating protein with its receptor. Residues critical for beta chain binding and evidence for independent alpha chain binding."
J. Biol. Chem. 274:29937-29943(1999) [PubMed] [Europe PMC] [Abstract]

"Macrophage-stimulating protein and RON receptor tyrosine kinase: potential regulators of macrophage inflammatory activities."
Scand. J. Immunol. 56:545-553(2002) [PubMed] [Europe PMC] [Abstract]

"c-Cbl is a critical modulator of the Ron tyrosine kinase receptor."
Oncogene 22:3669-3679(2003) [PubMed] [Europe PMC] [Abstract]

"Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus."
Proc. Natl. Acad. Sci. U.S.A. 100:4580-4585(2003) [PubMed] [Europe PMC] [Abstract]

"Interplay between scatter factor receptors and B plexins controls invasive growth."
Oncogene 23:5131-5137(2004) [PubMed] [Europe PMC] [Abstract]

"The C terminus of RON tyrosine kinase plays an autoinhibitory role."
J. Biol. Chem. 280:8893-8900(2005) [PubMed] [Europe PMC] [Abstract]

"The RON receptor tyrosine kinase promotes MSP-independent cell spreading and survival in breast epithelial cells."
Oncogene 28:279-288(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET."
J. Biol. Chem. 286:32762-32774(2011) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis."
Biochemistry 49:7972-7974(2010) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the Sema-PSI extracellular domain of human RON receptor tyrosine kinase."
PLoS ONE 7:E41912-E41912(2012) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]