Platelet Membrane Glycoprotein IV (GP4)

CD36; FAT; GP3B; GPIV; PASIV; SCARB3; GP88; GpIIIb; Glycoprotein IIIb; Collagen Type I Receptor; Thrombospondin Receptor; Fatty acid translocase; Platelet collagen receptor

SPN	V304
HGNC	1663
MGI	107899
PubMed	1715582
RGD	2301
UniProt	P16671
Wiki	CD36

CD36 is a membrane glycoprotein on platelets, monocytes and umbilical vein endothelial cells. CD36 is preferentially found within lipid rafts, which facilitates its association with receptors, signalling and adapter molecules. CD36 binds to collagen, Thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. CD36 plays a key role in both phagocytosis and lipid recycling, for constant production of mature spermatozoa. Mutations in this gene cause platelet glycoprotein deficiency. Three alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. Thrombospondins are widely distributed proteins that influence a variety of adhesive processes and CD36 may have important functions as a cell adhesion molecule.

Reference

"CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes."
Cell 58:95-101(1989) [PubMed] [Europe PMC] [Abstract]

"Characterization of two alternatively spliced 5'-untranslated exons of the human CD36 gene in different cell types."
Gene 133:205-212(1993) [PubMed] [Europe PMC] [Abstract]

"Cloning of the cDNA encoding human platelet CD36: comparison to PCR amplified fragments of monocyte, endothelial and HEL cells."
Thromb. Haemost. 70:500-505(1993) [PubMed] [Europe PMC] [Abstract]

"Structural organization of the gene for human CD36 glycoprotein."
J. Biol. Chem. 269:18985-18991(1994) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of platelet glycoprotein IV (CD36)."
J. Biol. Chem. 264:7570-7575(1989) [PubMed] [Europe PMC] [Abstract]

"Variability of the CD36 gene in West Africa."
Hum. Mutat. 18:444-450(2001) [PubMed] [Europe PMC] [Abstract]

"Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2."
Genomics 17:759-761(1993) [PubMed] [Europe PMC] [Abstract]

"Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]

"Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding."
Biochem. Biophys. Res. Commun. 182:1208-1217(1992) [PubMed] [Europe PMC] [Abstract]

"CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails."
J. Biol. Chem. 271:22315-22320(1996) [PubMed] [Europe PMC] [Abstract]

"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]

"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer."
Nat. Immunol. 11:155-161(2010) [PubMed] [Europe PMC] [Abstract]

"Molecular basis of CD36 deficiency. Evidence that a 478C-->T substitution (proline90-->serine) in CD36 cDNA accounts for CD36 deficiency."
J. Clin. Invest. 95:1040-1046(1995) [PubMed] [Europe PMC] [Abstract]

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 23:373-373(1999)

"Malaria susceptibility and CD36 mutation."
Nature 405:1015-1016(2000) [PubMed] [Europe PMC] [Abstract]

"Identification of cryptic splice site, exon skipping, and novel point mutations in type I CD36 deficiency."
J. Med. Genet. 39:286-291(2002) [PubMed] [Europe PMC] [Abstract]

"CD36 polymorphism is associated with protection from cerebral malaria."
Am. J. Hum. Genet. 72:364-374(2003) [PubMed] [Europe PMC] [Abstract]

"A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians."
Hum. Mol. Genet. 13:2197-2205(2004) [PubMed] [Europe PMC] [Abstract]

Erratum
Hum. Mol. Genet. 14:3973-3973(2005)