Colony Stimulating Factor 2 Receptor Beta (CSF2Rb)

CD131; CSF2R-B; IL3-RB; IL3RB; CSF2-RB; Colony Stimulating Factor 2 Receptor,Beta,Low-Affinity(granulocyte-Macrophage); GM-CSF/IL-3/IL-5 receptor common beta subunit

SPN	V299
HGNC	2436
MGI	1339759
PubMed	21205713
RGD	620189
UniProt	P32927
Wiki	CSF2RB

The CSF2RB gene encodes the high-affinity beta subunit of a receptor for interleukin-5 (IL5R; 147851), granulocyte-macrophage CSF (CSF2R). In the mouse, 2 distinct but related genes, AIC2A (Csf2rb2) and AIC2B (Csf2rb1), encode the beta subunit common to Csf2r, Il5r, and Il3r (Gorman et al., 1992). Hara and Miyajima (1992) stated that the mouse AIC2B gene encodes a common beta subunit for the mouse Gmcsf and Il5 receptors, whereas AIC2A encodes a low-affinity Il3-binding protein by itself. Hara and Miyajima (1992) found that AIC2A formed a high-affinity Il3-binding protein when coexpressed with a mouse protein homologous to the human alpha subunit. In addition, AIC2B formed a high-affinity Il3-binding protein when coexpressed with the alpha subunit.

Reference

"Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor."
Proc. Natl. Acad. Sci. U.S.A. 87:9655-9659(1990) [PubMed] [Europe PMC] [Abstract]

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Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]

"CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction."
Oncogene 27:1397-1403(2008) [PubMed] [Europe PMC] [Abstract]

"Adult-onset hereditary pulmonary alveolar proteinosis caused by a single-base deletion in CSF2RB."
J. Med. Genet. 48:205-209(2011) [PubMed] [Europe PMC] [Abstract]

"The solution structure of the cytokine-binding domain of the common beta-chain of the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5."
J. Mol. Biol. 297:989-1001(2000) [PubMed] [Europe PMC] [Abstract]

"Structure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common beta-chain bound to an antagonist."
Blood 95:2491-2498(2000) [PubMed] [Europe PMC] [Abstract]

"Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration."
Cell 104:291-300(2001) [PubMed] [Europe PMC] [Abstract]

"An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope."
Acta Crystallogr. F 62:509-513(2006) [PubMed] [Europe PMC] [Abstract]

"The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation."
Cell 134:496-507(2008) [PubMed] [Europe PMC] [Abstract]

"Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression."
J. Clin. Invest. 100:2211-2217(1997) [PubMed] [Europe PMC] [Abstract]