Protein Tyrosine Phosphatase Receptor Type J (PTPRJ)
CD148; PTPR-J; DEP1; HPTPeta; R-PTP-ETA; SCC1; Protein-tyrosine phosphatase eta; Density-enhanced phosphatase 1
is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This PTP is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells (LAT). This PTP was also found to dephosphorylate PDGF beta receptor, and may be involved in UV-induced signal transduction.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV289Hu01 | Recombinant Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV289Hu01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | WB; IHC; ICC; IP. |
| PAV289Hu01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV289Hu01 | CLIA Kit for Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | CLIA assay for Antigen Detection |
| ELV289Hu01 | ELISA Kit for Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV289Mu01 | Recombinant Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV289Mu01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | WB; IHC; ICC; IP. |
| PAV289Mu01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV289Mu01 | CLIA Kit for Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | CLIA assay for Antigen Detection |
| ELV289Mu01 | ELISA Kit for Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV289Ra01 | Recombinant Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV289Ra01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | WB; IHC; ICC; IP. |
| PAV289Ra01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV289Ra01 | CLIA Kit for Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | CLIA assay for Antigen Detection |
| ELV289Ra01 | ELISA Kit for Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV289Ca01 | Recombinant Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV289Ca01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | WB; IHC; ICC; IP. |
| PAV289Ca01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV289Ca01 | CLIA Kit for Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | CLIA assay for Antigen Detection |
| ELV289Ca01 | ELISA Kit for Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV289Po01 | Recombinant Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV289Po01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | WB; IHC; ICC; IP. |
| PAV289Po01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV289Po01 | CLIA Kit for Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | CLIA assay for Antigen Detection |
| ELV289Po01 | ELISA Kit for Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV289Bo01 | Recombinant Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV289Bo01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | WB; IHC; ICC; IP. |
| PAV289Bo01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV289Bo01 | CLIA Kit for Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | CLIA assay for Antigen Detection |
| ELV289Bo01 | ELISA Kit for Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV289Rb01 | Recombinant Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV289Rb01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | WB; IHC; ICC; IP. |
| PAV289Rb01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV289Rb01 | CLIA Kit for Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | CLIA assay for Antigen Detection |
| ELV289Rb01 | ELISA Kit for Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV289Mo01 | Recombinant Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV289Mo01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | WB; IHC; ICC; IP. |
| PAV289Mo01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV289Mo01 | CLIA Kit for Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | CLIA assay for Antigen Detection |
| ELV289Mo01 | ELISA Kit for Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density."
Proc. Natl. Acad. Sci. U.S.A. 91:9680-9684(1994) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta."
Blood 84:4186-4194(1994) [PubMed] [Europe PMC] [Abstract]
"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers."
Nat. Genet. 31:295-300(2002) [PubMed] [Europe PMC] [Abstract]
"Identification of novel protein-tyrosine phosphatases in a human leukemia cell line, F-36P."
Leukemia 7:742-746(1993) [PubMed] [Europe PMC] [Abstract]
"CD148 is a membrane protein tyrosine phosphatase present in all hematopoietic lineages and is involved in signal transduction on lymphocytes."
Blood 91:2800-2809(1998) [PubMed] [Europe PMC] [Abstract]
"Negative regulation of human T cell activation by the receptor-type protein tyrosine phosphatase CD148."
J. Immunol. 161:3803-3807(1998) [PubMed] [Europe PMC] [Abstract]
"Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1."
J. Biol. Chem. 275:16219-16226(2000) [PubMed] [Europe PMC] [Abstract]
"Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation."
Mol. Cell. Biol. 21:2393-2403(2001) [PubMed] [Europe PMC] [Abstract]
"Primary sequence determinants responsible for site-selective dephosphorylation of the PDGF beta-receptor by the receptor-like protein tyrosine phosphatase DEP-1."
FEBS Lett. 517:27-31(2002) [PubMed] [Europe PMC] [Abstract]
"The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)."
Oncogene 21:7067-7076(2002) [PubMed] [Europe PMC] [Abstract]
"Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1."
J. Biol. Chem. 278:5728-5735(2003) [PubMed] [Europe PMC] [Abstract]
"The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling."
J. Cell Biol. 162:673-682(2003) [PubMed] [Europe PMC] [Abstract]
"The tyrosine phosphatase DEP-1 induces cytoskeletal rearrangements, aberrant cell-substratum interactions and a reduction in cell proliferation."
J. Cell Sci. 117:609-618(2004) [PubMed] [Europe PMC] [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
"The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins."
Cancer Res. 66:6280-6287(2006) [PubMed] [Europe PMC] [Abstract]
"DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients."
Oncogene 25:6319-6324(2006) [PubMed] [Europe PMC] [Abstract]
"The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase."
Biochem. J. 413:193-200(2008) [PubMed] [Europe PMC] [Abstract]
"The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis."
Blood 113:4942-4954(2009) [PubMed] [Europe PMC] [Abstract]
"An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis."
Curr. Biol. 19:1788-1798(2009) [PubMed] [Europe PMC] [Abstract]
"Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells."
J. Biol. Chem. 284:14997-15006(2009) [PubMed] [Europe PMC] [Abstract]
"Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases."
J. Biol. Chem. 284:22048-22058(2009) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival."
Mol. Cell. Biol. 29:241-253(2009) [PubMed] [Europe PMC] [Abstract]
"Loss of the protein-tyrosine phosphatase DEP-1/PTPRJ drives meningioma cell motility."
Brain Pathol. 21:405-418(2011) [PubMed] [Europe PMC] [Abstract]
"Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells."
Biochem. J. 426:65-72(2010) [PubMed] [Europe PMC] [Abstract]
"Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling."
J. Biol. Chem. 286:10918-10929(2011) [PubMed] [Europe PMC] [Abstract]
"Solution structure of the fourth FN3 domain of human receptor-type tyrosine-protein phosphatase eta."
Submitted (OCT-2006) to the PDB data bank
"The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis."
Oncogene 23:8432-8438(2004) [PubMed] [Europe PMC] [Abstract]