Poliovirus Receptor (PVR)

CD155; HVED; Necl-5; Tage4; Nectin-Like Protein 5

SPN	V284
HGNC	9705
MGI	107741
PubMed	10618374
RGD	3813
UniProt	P15151
Wiki	CD155

CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells.The role of CD155 in the immune system is unclear, though it may be involved in intestinal humoral immune responses.

This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells.

Reference

"Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily."
Cell 56:855-865(1989) [PubMed] [Europe PMC] [Abstract]

"The poliovirus receptor protein is produced both as membrane-bound and secreted forms."
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"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Functional domains of the poliovirus receptor."
Proc. Natl. Acad. Sci. U.S.A. 88:4104-4108(1991) [PubMed] [Europe PMC] [Abstract]

"N glycosylation of the virus binding domain is not essential for function of the human poliovirus receptor."
J. Virol. 66:7368-7373(1992) [PubMed] [Europe PMC] [Abstract]

"The poliovirus receptor CD155 mediates cell-to-matrix contacts by specifically binding to vitronectin."
Virology 285:218-227(2001) [PubMed] [Europe PMC] [Abstract]

"Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis."
J. Biol. Chem. 277:7897-7904(2002) [PubMed] [Europe PMC] [Abstract]

"Expression of the human poliovirus receptor/CD155 gene is activated by sonic hedgehog."
J. Biol. Chem. 277:25697-25702(2002) [PubMed] [Europe PMC] [Abstract]

"Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains."
J. Biol. Chem. 278:31251-31260(2003) [PubMed] [Europe PMC] [Abstract]

"Ligand stimulation of CD155alpha inhibits cell adhesion and enhances cell migration in fibroblasts."
Biochem. Biophys. Res. Commun. 319:1253-1264(2004) [PubMed] [Europe PMC] [Abstract]

"Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)."
Int. Immunol. 16:533-538(2004) [PubMed] [Europe PMC] [Abstract]

"Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome."
J. Virol. 78:7186-7198(2004) [PubMed] [Europe PMC] [Abstract]

"CD155/PVR plays a key role in cell motility during tumor cell invasion and migration."
BMC Cancer 4:73-73(2004) [PubMed] [Europe PMC] [Abstract]

"Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3."
J. Cell Biol. 171:165-173(2005) [PubMed] [Europe PMC] [Abstract]

"CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155)."
J. Immunol. 172:3994-3998(2004) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis."
Mol. Immunol. 42:463-469(2005) [PubMed] [Europe PMC] [Abstract]

"Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141."
Nat. Immunol. 6:181-188(2005) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells."
Nat. Immunol. 10:48-57(2009) [PubMed] [Europe PMC] [Abstract]

"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]

"Interaction of the poliovirus receptor with poliovirus."
Proc. Natl. Acad. Sci. U.S.A. 97:79-84(2000) [PubMed] [Europe PMC] [Abstract]

"Complexes of poliovirus serotypes with their common cellular receptor, CD155."
J. Virol. 77:4827-4835(2003) [PubMed] [Europe PMC] [Abstract]

"Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering."
Proc. Natl. Acad. Sci. U.S.A. 109:5399-5404(2012) [PubMed] [Europe PMC] [Abstract]