Octamer Binding Transcription Factor 2 (OCT2)
OTF2; POU2F2; POU Domain,Class 2,Transcription Factor 2; Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; Octamer-binding transcription factor 2
An understanding of development necessitates an understanding of the molecular mechanisms of cell type-specific gene expression. Using synthetic promoter constructions, it has been found that 2 sequences within immunoglobulin promoters are sufficient for lymphoid-specific promoter activity: an octamer, ATTTGCAT, and a TATA box. Staudt et al. (1988) isolated a cDNA which hybridized with mRNA transcripts that were largely restricted to lymphoid cells. The level of expression of the gene, termed OCT2, within different lymphoid cell lines correlated well with the amount of a nuclear factor called NFA2 that had previously been detected only in lymphoid cells. Ko et al. (1988) determined the DNA sequence of the OCT2 cDNA and showed that its gene product contains a homeobox.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV280Hu01 | Recombinant Octamer Binding Transcription Factor 2 (OCT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV280Hu01 | Monoclonal Antibody to Octamer Binding Transcription Factor 2 (OCT2) | WB; IHC; ICC; IP. |
| PAV280Hu01 | Polyclonal Antibody to Octamer Binding Transcription Factor 2 (OCT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV280Hu01 | CLIA Kit for Octamer Binding Transcription Factor 2 (OCT2) | CLIA assay for Antigen Detection |
| ELV280Hu01 | ELISA Kit for Octamer Binding Transcription Factor 2 (OCT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV280Mu01 | Recombinant Octamer Binding Transcription Factor 2 (OCT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV280Mu01 | Monoclonal Antibody to Octamer Binding Transcription Factor 2 (OCT2) | WB; IHC; ICC; IP. |
| PAV280Mu01 | Polyclonal Antibody to Octamer Binding Transcription Factor 2 (OCT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV280Mu01 | CLIA Kit for Octamer Binding Transcription Factor 2 (OCT2) | CLIA assay for Antigen Detection |
| ELV280Mu01 | ELISA Kit for Octamer Binding Transcription Factor 2 (OCT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV280Ra01 | Recombinant Octamer Binding Transcription Factor 2 (OCT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV280Ra01 | Monoclonal Antibody to Octamer Binding Transcription Factor 2 (OCT2) | WB; IHC; ICC; IP. |
| PAV280Ra01 | Polyclonal Antibody to Octamer Binding Transcription Factor 2 (OCT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV280Ra01 | CLIA Kit for Octamer Binding Transcription Factor 2 (OCT2) | CLIA assay for Antigen Detection |
| ELV280Ra01 | ELISA Kit for Octamer Binding Transcription Factor 2 (OCT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV280Ca01 | Recombinant Octamer Binding Transcription Factor 2 (OCT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV280Ca01 | Monoclonal Antibody to Octamer Binding Transcription Factor 2 (OCT2) | WB; IHC; ICC; IP. |
| PAV280Ca01 | Polyclonal Antibody to Octamer Binding Transcription Factor 2 (OCT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV280Ca01 | CLIA Kit for Octamer Binding Transcription Factor 2 (OCT2) | CLIA assay for Antigen Detection |
| ELV280Ca01 | ELISA Kit for Octamer Binding Transcription Factor 2 (OCT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV280Po01 | Recombinant Octamer Binding Transcription Factor 2 (OCT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV280Po01 | Monoclonal Antibody to Octamer Binding Transcription Factor 2 (OCT2) | WB; IHC; ICC; IP. |
| PAV280Po01 | Polyclonal Antibody to Octamer Binding Transcription Factor 2 (OCT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV280Po01 | CLIA Kit for Octamer Binding Transcription Factor 2 (OCT2) | CLIA assay for Antigen Detection |
| ELV280Po01 | ELISA Kit for Octamer Binding Transcription Factor 2 (OCT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV280Bo01 | Recombinant Octamer Binding Transcription Factor 2 (OCT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV280Bo01 | Monoclonal Antibody to Octamer Binding Transcription Factor 2 (OCT2) | WB; IHC; ICC; IP. |
| PAV280Bo01 | Polyclonal Antibody to Octamer Binding Transcription Factor 2 (OCT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV280Bo01 | CLIA Kit for Octamer Binding Transcription Factor 2 (OCT2) | CLIA assay for Antigen Detection |
| ELV280Bo01 | ELISA Kit for Octamer Binding Transcription Factor 2 (OCT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV280Rb01 | Recombinant Octamer Binding Transcription Factor 2 (OCT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV280Rb01 | Monoclonal Antibody to Octamer Binding Transcription Factor 2 (OCT2) | WB; IHC; ICC; IP. |
| PAV280Rb01 | Polyclonal Antibody to Octamer Binding Transcription Factor 2 (OCT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV280Rb01 | CLIA Kit for Octamer Binding Transcription Factor 2 (OCT2) | CLIA assay for Antigen Detection |
| ELV280Rb01 | ELISA Kit for Octamer Binding Transcription Factor 2 (OCT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV280Mo01 | Recombinant Octamer Binding Transcription Factor 2 (OCT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV280Mo01 | Monoclonal Antibody to Octamer Binding Transcription Factor 2 (OCT2) | WB; IHC; ICC; IP. |
| PAV280Mo01 | Polyclonal Antibody to Octamer Binding Transcription Factor 2 (OCT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV280Mo01 | CLIA Kit for Octamer Binding Transcription Factor 2 (OCT2) | CLIA assay for Antigen Detection |
| ELV280Mo01 | ELISA Kit for Octamer Binding Transcription Factor 2 (OCT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains."
Genes Dev. 2:1570-1581(1988) [PubMed] [Europe PMC] [Abstract]
"A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein."
Nature 336:551-557(1988) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells."
Nature 336:544-551(1988) [PubMed] [Europe PMC] [Abstract]
"Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells."
EMBO J. 9:1625-1634(1990) [PubMed] [Europe PMC] [Abstract]
"Short introns interrupting the Oct-2 POU domain may prevent recombination between POU family genes without interfering with potential POU domain 'shuffling' in evolution."
Biol. Chem. Hoppe-Seyler 375:675-683(1994) [PubMed] [Europe PMC] [Abstract]
"A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain."
Cell 55:135-144(1988) [PubMed] [Europe PMC] [Abstract]
"Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter."
Cell 68:755-767(1992) [PubMed] [Europe PMC] [Abstract]
"Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA)."
EMBO J. 7:4221-4229(1988) [PubMed] [Europe PMC] [Abstract]
"Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter."
J. Biol. Chem. 274:26713-26719(1999) [PubMed] [Europe PMC] [Abstract]
"Solution structure of a POU-specific homeodomain: 3D-NMR studies of human B-cell transcription factor Oct-2."
Biochemistry 33:9845-9855(1994) [PubMed] [Europe PMC] [Abstract]