A Disintegrin And Metalloprotease 17 (ADAM17)

CD156b; TACE; CSVP; Tumor Necrosis Factor,Alpha,Converting Enzyme; Disintegrin and metalloproteinase domain-containing protein 17; Snake venom-like protease

SPN	V279
HGNC	195
MGI	1096335
PubMed	23441135
RGD	620404
UniProt	P78536
Wiki	ADAM17

ADAM17 is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases. ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha (TNF-alpha;) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. This process, which is also known as 'shedding', involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-alpha;), and is of known physiological importance.

ADAM17 was the first 'sheddase' to be identified, and is also understood to play a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands, and enzymes.

Reference

"Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha."
Nature 385:733-736(1997) [PubMed] [Europe PMC] [Abstract]

"A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells."
Nature 385:729-733(1997) [PubMed] [Europe PMC] [Abstract]

"TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha."
J. Immunol. 160:4570-4579(1998) [PubMed] [Europe PMC] [Abstract]

"Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding."
Mol. Biol. Cell 13:2031-2044(2002) [PubMed] [Europe PMC] [Abstract]

"Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding."
J. Biol. Chem. 278:3386-3394(2003) [PubMed] [Europe PMC] [Abstract]

"Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide."
J. Biol. Chem. 278:18617-18627(2003) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Junctional adhesion molecule-C is a soluble mediator of angiogenesis."
J. Immunol. 185:1777-1785(2010) [PubMed] [Europe PMC] [Abstract]

"Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation."
Mol. Cell 37:551-566(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Inflammatory skin and bowel disease linked to ADAM17 deletion."
N. Engl. J. Med. 365:1502-1508(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality."
Nature 504:456-459(2013) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein."
J. Virol. 88:1293-1307(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme."
Proc. Natl. Acad. Sci. U.S.A. 95:3408-3412(1998) [PubMed] [Europe PMC] [Abstract]