Large Multifunctional Peptidase 7 (LMP7)

PSMB8; RING10; PSMB5i, Beta5i; Proteasome(Prosome,Macropain)Subunit,Beta Type 8; Multicatalytic endopeptidase complex subunit C13; Really interesting new gene 10 protein

SPN	V278
HGNC	9545
MGI	1346527
PubMed	8301122
RGD	3426
UniProt	P28062
Wiki	PSMB8

• The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.

• LMP7 encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex).

Reference

"The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing."
Eur. J. Immunol. 23:860-866(1993) [PubMed] [Europe PMC] [Abstract]

"DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing."
J. Mol. Biol. 228:433-441(1992) [PubMed] [Europe PMC] [Abstract]

"A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC."
Nature 353:357-360(1991) [PubMed] [Europe PMC] [Abstract]

"Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits."
J. Biol. Chem. 267:22131-22140(1992) [PubMed] [Europe PMC] [Abstract]

"Different genomic structure of mouse and human Lmp7 genes: characterization of MHC-encoded proteasome genes."
Immunogenetics 38:373-379(1993) [PubMed] [Europe PMC] [Abstract]

"Evolutionary dynamics of non-coding sequences within the class II region of the human MHC."
J. Mol. Biol. 255:1-13(1996) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Two newly discovered alleles of major histocompatibility complex-encoded LMP7 in Korean populations."
Hum. Immunol. 46:61-64(1996) [PubMed] [Europe PMC] [Abstract]

"Replacement of proteasome subunits X and Y by LMP7 and LMP2 induced by interferon-gamma for acquirement of the functional diversity responsible for antigen processing."
FEBS Lett. 343:85-88(1994) [PubMed] [Europe PMC] [Abstract]

"Proteasome subunits X and Y alter peptidase activities in opposite ways to the interferon-gamma-induced subunits LMP2 and LMP7."
J. Biol. Chem. 271:17275-17280(1996) [PubMed] [Europe PMC] [Abstract]

"Tumor necrosis factor-alpha induces coordinated changes in major histocompatibility class I presentation pathway, resulting in increased stability of class I complexes at the cell surface."
Blood 98:1108-1115(2001) [PubMed] [Europe PMC] [Abstract]

"Bipartite regulation of different components of the MHC class I antigen-processing machinery during dendritic cell maturation."
Int. Immunol. 13:1515-1523(2001) [PubMed] [Europe PMC] [Abstract]

"Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits."
FEBS Lett. 553:200-204(2003) [PubMed] [Europe PMC] [Abstract]

"Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach."
Toxicon 44:597-608(2004) [PubMed] [Europe PMC] [Abstract]

"IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome."
FEBS Lett. 579:2781-2787(2005) [PubMed] [Europe PMC] [Abstract]

"Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome."
Mol. Immunol. 42:137-141(2005) [PubMed] [Europe PMC] [Abstract]

"IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response."
Proc. Natl. Acad. Sci. U.S.A. 102:9241-9246(2005) [PubMed] [Europe PMC] [Abstract]

"Tumor cell lines expressing the proteasome subunit isoform LMP7E1 exhibit immunoproteasome deficiency."
Cancer Res. 66:649-652(2006) [PubMed] [Europe PMC] [Abstract]

"Heat shock up-regulates lmp2 and lmp7 and enhances presentation of immunoproteasome-dependent epitopes."
J. Immunol. 177:8393-8399(2006) [PubMed] [Europe PMC] [Abstract]

"Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis."
Inflamm. Bowel Dis. 13:807-821(2007) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the interferon-inducible immunoproteasome."
Arterioscler. Thromb. Vasc. Biol. 29:1213-1219(2009) [PubMed] [Europe PMC] [Abstract]

"Herpes simplex virus type I infection of mature dendritic cells leads to reduced LMP7-mRNA-expression levels."
Immunobiology 214:861-867(2009) [PubMed] [Europe PMC] [Abstract]

"A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis."
Nat. Med. 15:781-787(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans."
J. Clin. Invest. 121:4150-4160(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"PSMB8 encoding the beta5i proteasome subunit is mutated in joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy syndrome."
Am. J. Hum. Genet. 87:866-872(2010) [PubMed] [Europe PMC] [Abstract]

"Mutations in proteasome subunit beta type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity."
Arthritis Rheum. 64:895-907(2012) [PubMed] [Europe PMC] [Abstract]

"Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome."
Proc. Natl. Acad. Sci. U.S.A. 108:14914-14919(2011) [PubMed] [Europe PMC] [Abstract]