Lymphotoxin Beta (LTb)

LT-B; p33; TNFC; TNF-C; TNFSF3; Tumor necrosis factor ligand superfamily member 3; Tumor Necrosis Factor C

SPN	V274
HGNC	6711
MGI	104796
PubMed	15845449
RGD	1303162
UniProt	Q06643
Wiki	LTB

Lymphotoxin beta (TNF superfamily, member 3), also known as LTB, is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV274Hu01	Recombinant Lymphotoxin Beta (LTb)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV274Hu01	Monoclonal Antibody to Lymphotoxin Beta (LTb)	WB; IHC; ICC; IP.
Antibodies	PAV274Hu01	Polyclonal Antibody to Lymphotoxin Beta (LTb)	WB; IHC; ICC; IF.
Assay Kits	CLV274Hu01	CLIA Kit for Lymphotoxin Beta (LTb)	CLIA assay for Antigen Detection
Assay Kits	ELV274Hu01	ELISA Kit for Lymphotoxin Beta (LTb)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV274Mu01	Recombinant Lymphotoxin Beta (LTb)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV274Mu01	Monoclonal Antibody to Lymphotoxin Beta (LTb)	WB; IHC; ICC; IP.
Antibodies	PAV274Mu01	Polyclonal Antibody to Lymphotoxin Beta (LTb)	WB; IHC; ICC; IF.
Assay Kits	CLV274Mu01	CLIA Kit for Lymphotoxin Beta (LTb)	CLIA assay for Antigen Detection
Assay Kits	ELV274Mu01	ELISA Kit for Lymphotoxin Beta (LTb)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV274Ra01	Recombinant Lymphotoxin Beta (LTb)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV274Ra01	Monoclonal Antibody to Lymphotoxin Beta (LTb)	WB; IHC; ICC; IP.
Antibodies	PAV274Ra01	Polyclonal Antibody to Lymphotoxin Beta (LTb)	WB; IHC; ICC; IF.
Assay Kits	CLV274Ra01	CLIA Kit for Lymphotoxin Beta (LTb)	CLIA assay for Antigen Detection
Assay Kits	ELV274Ra01	ELISA Kit for Lymphotoxin Beta (LTb)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV274Ca01	Recombinant Lymphotoxin Beta (LTb)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV274Ca01	Monoclonal Antibody to Lymphotoxin Beta (LTb)	WB; IHC; ICC; IP.
Antibodies	PAV274Ca01	Polyclonal Antibody to Lymphotoxin Beta (LTb)	WB; IHC; ICC; IF.
Assay Kits	CLV274Ca01	CLIA Kit for Lymphotoxin Beta (LTb)	CLIA assay for Antigen Detection
Assay Kits	ELV274Ca01	ELISA Kit for Lymphotoxin Beta (LTb)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV274Po01	Recombinant Lymphotoxin Beta (LTb)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV274Po01	Monoclonal Antibody to Lymphotoxin Beta (LTb)	WB; IHC; ICC; IP.
Antibodies	PAV274Po01	Polyclonal Antibody to Lymphotoxin Beta (LTb)	WB; IHC; ICC; IF.
Assay Kits	CLV274Po01	CLIA Kit for Lymphotoxin Beta (LTb)	CLIA assay for Antigen Detection
Assay Kits	ELV274Po01	ELISA Kit for Lymphotoxin Beta (LTb)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV274Bo01	Recombinant Lymphotoxin Beta (LTb)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV274Bo01	Monoclonal Antibody to Lymphotoxin Beta (LTb)	WB; IHC; ICC; IP.
Antibodies	PAV274Bo01	Polyclonal Antibody to Lymphotoxin Beta (LTb)	WB; IHC; ICC; IF.
Assay Kits	CLV274Bo01	CLIA Kit for Lymphotoxin Beta (LTb)	CLIA assay for Antigen Detection
Assay Kits	ELV274Bo01	ELISA Kit for Lymphotoxin Beta (LTb)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV274Rb01	Recombinant Lymphotoxin Beta (LTb)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV274Rb01	Monoclonal Antibody to Lymphotoxin Beta (LTb)	WB; IHC; ICC; IP.
Antibodies	PAV274Rb01	Polyclonal Antibody to Lymphotoxin Beta (LTb)	WB; IHC; ICC; IF.
Assay Kits	CLV274Rb01	CLIA Kit for Lymphotoxin Beta (LTb)	CLIA assay for Antigen Detection
Assay Kits	ELV274Rb01	ELISA Kit for Lymphotoxin Beta (LTb)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV274Mo01	Recombinant Lymphotoxin Beta (LTb)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV274Mo01	Monoclonal Antibody to Lymphotoxin Beta (LTb)	WB; IHC; ICC; IP.
Antibodies	PAV274Mo01	Polyclonal Antibody to Lymphotoxin Beta (LTb)	WB; IHC; ICC; IF.
Assay Kits	CLV274Mo01	CLIA Kit for Lymphotoxin Beta (LTb)	CLIA assay for Antigen Detection
Assay Kits	ELV274Mo01	ELISA Kit for Lymphotoxin Beta (LTb)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface."
Cell 72:847-856(1993) [PubMed] [Europe PMC] [Abstract]

"Identification of two lymphotoxin beta isoforms expressed in human lymphoid cell lines and non-Hodgkin's lymphomas."
Biochem. Biophys. Res. Commun. 238:273-276(1997) [PubMed] [Europe PMC] [Abstract]

"A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC."
J. Immunol. 162:4745-4754(1999) [PubMed] [Europe PMC] [Abstract]

"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]