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Granulocyte Chemotactic Protein 2 (GCP2)

CXCL6; SCYB6; GCP2; CKA-3; Chemokine(C-X-C-Motif)ligand 6; Small Inducible Cytokine Subfamily B(Cys-X-Cys)Member 6; Chemokine alpha 3; Small-inducible cytokine B6

Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes. It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2.The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.

The GCP2 gene encodes a propeptide of 114 amino acids. Despite 85% identity of the first 270 nucleotides 5-prime of the transcription start sites, GCP2 and the other CXC chemokine gene ENA78 showed cell-specific differences in regulation.In vivo studies in rabbit demonstrated that GCP2 is a potent inflammatory mediator.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV265Hu01 Recombinant Granulocyte Chemotactic Protein 2 (GCP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV265Hu01 Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) WB; IHC; ICC; IP.
PAV265Hu01 Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) WB; IHC; ICC; IF.
Assay Kits CLV265Hu01 CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) CLIA assay for Antigen Detection
ELV265Hu01 ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV265Mu01 Recombinant Granulocyte Chemotactic Protein 2 (GCP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV265Mu01 Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) WB; IHC; ICC; IP.
PAV265Mu01 Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) WB; IHC; ICC; IF.
Assay Kits CLV265Mu01 CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) CLIA assay for Antigen Detection
ELV265Mu01 ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV265Ra01 Recombinant Granulocyte Chemotactic Protein 2 (GCP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV265Ra01 Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) WB; IHC; ICC; IP.
PAV265Ra01 Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) WB; IHC; ICC; IF.
Assay Kits CLV265Ra01 CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) CLIA assay for Antigen Detection
ELV265Ra01 ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV265Ca01 Recombinant Granulocyte Chemotactic Protein 2 (GCP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV265Ca01 Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) WB; IHC; ICC; IP.
PAV265Ca01 Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) WB; IHC; ICC; IF.
Assay Kits CLV265Ca01 CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) CLIA assay for Antigen Detection
ELV265Ca01 ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV265Po01 Recombinant Granulocyte Chemotactic Protein 2 (GCP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV265Po01 Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) WB; IHC; ICC; IP.
PAV265Po01 Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) WB; IHC; ICC; IF.
Assay Kits CLV265Po01 CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) CLIA assay for Antigen Detection
ELV265Po01 ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV265Bo01 Recombinant Granulocyte Chemotactic Protein 2 (GCP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV265Bo01 Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) WB; IHC; ICC; IP.
PAV265Bo01 Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) WB; IHC; ICC; IF.
Assay Kits CLV265Bo01 CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) CLIA assay for Antigen Detection
ELV265Bo01 ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV265Rb01 Recombinant Granulocyte Chemotactic Protein 2 (GCP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV265Rb01 Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) WB; IHC; ICC; IP.
PAV265Rb01 Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) WB; IHC; ICC; IF.
Assay Kits CLV265Rb01 CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) CLIA assay for Antigen Detection
ELV265Rb01 ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV265Mo01 Recombinant Granulocyte Chemotactic Protein 2 (GCP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV265Mo01 Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) WB; IHC; ICC; IP.
PAV265Mo01 Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) WB; IHC; ICC; IF.
Assay Kits CLV265Mo01 CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) CLIA assay for Antigen Detection
ELV265Mo01 ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning and characterization of the human granulocyte chemotactic protein-2 gene."
J. Immunol. 158:5257-5266(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell-derived neutrophil activating peptide-78 mRNAs."
Eur. J. Biochem. 243:762-769(1997) [PubMed] [Europe PMC] [Abstract]

"Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines."
Biochemistry 32:10170-10177(1993) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8."
J. Immunol. 150:1000-1010(1993) [PubMed] [Europe PMC] [Abstract]

"The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial."
Antimicrob. Agents Chemother. 52:2599-2607(2008) [PubMed] [Europe PMC] [Abstract]