Myeloid Progenitor Inhibitory Factor 1 (MPIF1)

CCL23; SCYA23; Ckb-8; MIP-3; CKb8; Chemokine(C-C-Motif)ligand 23; Small Inducible Cytokine Subfamily A(Cys-Cys)Member 23; Macrophage inflammatory protein 3

SPN	V261
HGNC	10622
PubMed	17130244
UniProt	P55773
Wiki	CCL23

Chemokine (C-C motif) ligand 23 (CCL23) is a small cytokine belonging to the CC chemokine family that is also known as Macrophage inflammatory protein 3 (MIP-3) and Myeloid progenitor inhibitory factor 1 (MPIF-1). CCL23 is predominantly expressed in lung and liver tissue, but is also found in bone marrow and placenta.

It is also expressed in some cell lines of myeloid origin. CCL23 is highly chemotactic for resting T cells and monocytes and slightly chemotactic for neutrophils. It has also been attributed to an inhibitory activity on hematopoietic progenitor cells.The gene for CCL23 is located on human chromosome 17 in a locus containing several other CC chemokines. CCL23 is a ligand for the chemokine receptor CCR1.

Reference

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Patent number US5504003, 02-APR-1996

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J. Exp. Med. 185:1163-1172(1997) [PubMed] [Europe PMC] [Abstract]

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Blood 91:3118-3126(1998) [PubMed] [Europe PMC] [Abstract]

"Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES."
J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

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"Proteolytic activation of alternative CCR1 ligands in inflammation."
J. Immunol. 174:7341-7351(2005) [PubMed] [Europe PMC] [Abstract]

"Solution structure and dynamics of myeloid progenitor inhibitory factor-1 (MPIF-1), a novel monomeric CC chemokine."
J. Biol. Chem. 276:4909-4916(2001) [PubMed] [Europe PMC] [Abstract]