Secondary Lymphoid Tissue Chemokine (SLC)

CCL21; 6Ckine; CKb9; ECL; SCYA21; TCA4; ECL; Chemokine(C-C-Motif)Ligand 21; Beta Chemokine Exodus-2; Efficient Chemoattractant For Lymphocytes

SPN	V260
HGNC	10620
MGI	1349183
PubMed	9670974
UniProt	O00585
Wiki	CCL21

Chemokine (C-C motif) ligand 21 (CCL21) is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family.

Reference

"Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13."
J. Biol. Chem. 272:19518-19524(1997) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of a novel beta chemokine containing six conserved cysteines."
J. Immunol. 159:1589-1593(1997) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension."
J. Immunol. 159:2554-2558(1997) [PubMed] [Europe PMC] [Abstract]

"A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes."
Proc. Natl. Acad. Sci. U.S.A. 95:258-263(1998) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7."
J. Biol. Chem. 273:7118-7122(1998) [PubMed] [Europe PMC] [Abstract]

"Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR."
J. Biol. Chem. 288:7169-7181(2013) [PubMed] [Europe PMC] [Abstract]

"Solution structure of CCL21 and identification of a putative CCR7 binding site."
Biochemistry 51:733-735(2012) [PubMed] [Europe PMC] [Abstract]