Lymphocyte Function Associated Antigen 2 (LFA2)
CD2; SRBC; T11; T-Cell Surface Antigen T11/Leu-5; LFA-3 Receptor; Erythrocyte Receptor; Rosette Receptor; Sheep Red Blood Cell Receptor
CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor.
It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells. In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells.
Due to its structural characteristics, CD2 is a member of the immunoglobulin superfamily; it possesses two immunoglobulin-like domains in its extracellular portion.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV259Hu01 | Recombinant Lymphocyte Function Associated Antigen 2 (LFA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV259Hu01 | Monoclonal Antibody to Lymphocyte Function Associated Antigen 2 (LFA2) | WB; IHC; ICC; IP. |
| PAV259Hu01 | Polyclonal Antibody to Lymphocyte Function Associated Antigen 2 (LFA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV259Hu01 | CLIA Kit for Lymphocyte Function Associated Antigen 2 (LFA2) | CLIA assay for Antigen Detection |
| ELV259Hu01 | ELISA Kit for Lymphocyte Function Associated Antigen 2 (LFA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV259Mu01 | Recombinant Lymphocyte Function Associated Antigen 2 (LFA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV259Mu01 | Monoclonal Antibody to Lymphocyte Function Associated Antigen 2 (LFA2) | WB; IHC; ICC; IP. |
| PAV259Mu01 | Polyclonal Antibody to Lymphocyte Function Associated Antigen 2 (LFA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV259Mu01 | CLIA Kit for Lymphocyte Function Associated Antigen 2 (LFA2) | CLIA assay for Antigen Detection |
| ELV259Mu01 | ELISA Kit for Lymphocyte Function Associated Antigen 2 (LFA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV259Ra01 | Recombinant Lymphocyte Function Associated Antigen 2 (LFA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV259Ra01 | Monoclonal Antibody to Lymphocyte Function Associated Antigen 2 (LFA2) | WB; IHC; ICC; IP. |
| PAV259Ra01 | Polyclonal Antibody to Lymphocyte Function Associated Antigen 2 (LFA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV259Ra01 | CLIA Kit for Lymphocyte Function Associated Antigen 2 (LFA2) | CLIA assay for Antigen Detection |
| ELV259Ra01 | ELISA Kit for Lymphocyte Function Associated Antigen 2 (LFA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV259Ca01 | Recombinant Lymphocyte Function Associated Antigen 2 (LFA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV259Ca01 | Monoclonal Antibody to Lymphocyte Function Associated Antigen 2 (LFA2) | WB; IHC; ICC; IP. |
| PAV259Ca01 | Polyclonal Antibody to Lymphocyte Function Associated Antigen 2 (LFA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV259Ca01 | CLIA Kit for Lymphocyte Function Associated Antigen 2 (LFA2) | CLIA assay for Antigen Detection |
| ELV259Ca01 | ELISA Kit for Lymphocyte Function Associated Antigen 2 (LFA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV259Po01 | Recombinant Lymphocyte Function Associated Antigen 2 (LFA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV259Po01 | Monoclonal Antibody to Lymphocyte Function Associated Antigen 2 (LFA2) | WB; IHC; ICC; IP. |
| PAV259Po01 | Polyclonal Antibody to Lymphocyte Function Associated Antigen 2 (LFA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV259Po01 | CLIA Kit for Lymphocyte Function Associated Antigen 2 (LFA2) | CLIA assay for Antigen Detection |
| ELV259Po01 | ELISA Kit for Lymphocyte Function Associated Antigen 2 (LFA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV259Bo01 | Recombinant Lymphocyte Function Associated Antigen 2 (LFA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV259Bo01 | Monoclonal Antibody to Lymphocyte Function Associated Antigen 2 (LFA2) | WB; IHC; ICC; IP. |
| PAV259Bo01 | Polyclonal Antibody to Lymphocyte Function Associated Antigen 2 (LFA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV259Bo01 | CLIA Kit for Lymphocyte Function Associated Antigen 2 (LFA2) | CLIA assay for Antigen Detection |
| ELV259Bo01 | ELISA Kit for Lymphocyte Function Associated Antigen 2 (LFA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV259Rb01 | Recombinant Lymphocyte Function Associated Antigen 2 (LFA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV259Rb01 | Monoclonal Antibody to Lymphocyte Function Associated Antigen 2 (LFA2) | WB; IHC; ICC; IP. |
| PAV259Rb01 | Polyclonal Antibody to Lymphocyte Function Associated Antigen 2 (LFA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV259Rb01 | CLIA Kit for Lymphocyte Function Associated Antigen 2 (LFA2) | CLIA assay for Antigen Detection |
| ELV259Rb01 | ELISA Kit for Lymphocyte Function Associated Antigen 2 (LFA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV259Mo01 | Recombinant Lymphocyte Function Associated Antigen 2 (LFA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV259Mo01 | Monoclonal Antibody to Lymphocyte Function Associated Antigen 2 (LFA2) | WB; IHC; ICC; IP. |
| PAV259Mo01 | Polyclonal Antibody to Lymphocyte Function Associated Antigen 2 (LFA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV259Mo01 | CLIA Kit for Lymphocyte Function Associated Antigen 2 (LFA2) | CLIA assay for Antigen Detection |
| ELV259Mo01 | ELISA Kit for Lymphocyte Function Associated Antigen 2 (LFA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes."
Proc. Natl. Acad. Sci. U.S.A. 85:1615-1619(1988) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure."
Proc. Natl. Acad. Sci. U.S.A. 84:3365-3369(1987) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen."
Proc. Natl. Acad. Sci. U.S.A. 83:8718-8722(1986) [PubMed] [Europe PMC] [Abstract]
Erratum
Proc. Natl. Acad. Sci. U.S.A. 84:7256-7256(1987)
"Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes."
Proc. Natl. Acad. Sci. U.S.A. 84:2941-2945(1987) [PubMed] [Europe PMC] [Abstract]
"The structure of the human CD2 gene and its expression in transgenic mice."
EMBO J. 7:1675-1682(1988) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2)."
Nature 329:842-846(1987) [PubMed] [Europe PMC] [Abstract]
"Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59."
Science 256:1805-1807(1992) [PubMed] [Europe PMC] [Abstract]
"A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion."
EMBO J. 17:7320-7336(1998) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5-A resolution."
Structure 2:755-766(1994) [PubMed] [Europe PMC] [Abstract]
"Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2."
Structure 1:69-81(1993) [PubMed] [Europe PMC] [Abstract]
"Conformation and function of the N-linked glycan in the adhesion domain of human CD2."
Science 269:1273-1278(1995) [PubMed] [Europe PMC] [Abstract]
"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]