Receptor I For The Fc Region Of Immunoglobulin G (FcgRI)

CD64; FCGR1; FCGR1A; FCGR1B; FCGR1C; FcgRIA; CD64A; FcgRIB; CD64B; FcgRIC; CD64C; High affinity immunoglobulin gamma Fc receptor I

SPN	V257
HGNC	3613
MGI	95498
PubMed	2955043
RGD	1309912
UniProt	P12314
Wiki	CD64

CD64 is a type of integral membrane glycoprotein known as an Fc receptor that binds monomeric IgG-type antibodies with high affinity. It is more commonly known as Fc-gamma receptor 1 (Fc gamma RI). After binding IgG, CD64 interacts with an accessory chain known as the common gamma chain (gamma chain), which possesses an ITAM motif that is necessary for triggering cellular activation.Structurally CD64 is composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail.CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFN gamma; and G-CSF can induce CD64 expression on these cells.

Reference

"Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI)."
Nucleic Acids Res. 16:11824-11824(1988) [PubMed] [Europe PMC] [Abstract]

"Isolation and expression of functional high-affinity Fc receptor complementary DNAs."
Science 243:378-381(1989) [PubMed] [Europe PMC] [Abstract]

"Novel Fc gamma receptor I family gene products in human mononuclear cells."
J. Clin. Invest. 90:2102-2109(1992) [PubMed] [Europe PMC] [Abstract]

"Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure."
J. Exp. Med. 176:1115-1123(1992) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products."
J. Biol. Chem. 267:15692-15700(1992) [PubMed] [Europe PMC] [Abstract]

"Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn."
J. Exp. Med. 180:1165-1170(1994) [PubMed] [Europe PMC] [Abstract]

"FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo."
Blood 87:3593-3599(1996) [PubMed] [Europe PMC] [Abstract]

"Molecular characterization of six variant Fcgamma receptor class I (CD64) transcripts."
Mol. Immunol. 35:943-954(1998) [PubMed] [Europe PMC] [Abstract]

"The FcgammaRIa (CD64) ligand binding chain triggers major histocompatibility complex class II antigen presentation independently of its associated FcR gamma-chain."
Blood 94:808-817(1999) [PubMed] [Europe PMC] [Abstract]

"The cytoplasmic domain of human FcgammaRIa alters the functional properties of the FcgammaRI.gamma-chain receptor complex."
J. Biol. Chem. 274:30328-30333(1999) [PubMed] [Europe PMC] [Abstract]

"The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells."
J. Biol. Chem. 275:20480-20487(2000) [PubMed] [Europe PMC] [Abstract]

"Fcgamma receptor transmembrane domains: role in cell surface expression, gamma chain interaction, and phagocytosis."
Blood 101:4479-4484(2003) [PubMed] [Europe PMC] [Abstract]

"Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity."
Proc. Natl. Acad. Sci. U.S.A. 101:10392-10397(2004) [PubMed] [Europe PMC] [Abstract]

"Filamin A stabilizes FcgammaRI surface expression and prevents its lysosomal routing."
J. Immunol. 180:3938-3945(2008) [PubMed] [Europe PMC] [Abstract]

"Protein 4.1G binds to a unique motif within the FcgammaRI cytoplasmic tail."
Mol. Immunol. 45:2069-2075(2008) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of Fcgamma receptor I and its implication in high affinity gamma-immunoglobulin binding."
J. Biol. Chem. 286:40608-40613(2011) [PubMed] [Europe PMC] [Abstract]