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Cytohesin 2 (CYTH2)
Cytohesin 2 (CYTH2)
CYT2; PSCD2; ARNO; CTS18.1; PSCD2L; SEC7L; Sec7p-Like; Pleckstrin Homology,Sec7 And Coiled-Coil Domains 2; ARF exchange factor; ARF nucleotide-binding site opener
Pleckstrin homology, Sec7 and coiled/coil domains 2 (PSCD2) is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. PSCD2 exhibits GEP activity in vitro with ARF1, ARF3, and ARF6. PSCD2 protein is 83% homologous to PSCD1. Two transcript variants encoding different isoforms have been found for this gene.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
V252Hu01
Recombinant Cytohesin 2 (CYTH2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cytohesin 2 (CYTH2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IP.
PV252Hu01
Polyclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cytohesin 2 (CYTH2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cytohesin 2 (CYTH2) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cytohesin 2 (CYTH2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cytohesin 2 (CYTH2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cytohesin 2 (CYTH2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cytohesin 2 (CYTH2) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cytohesin 2 (CYTH2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cytohesin 2 (CYTH2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cytohesin 2 (CYTH2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cytohesin 2 (CYTH2) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cytohesin 2 (CYTH2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cytohesin 2 (CYTH2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cytohesin 2 (CYTH2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cytohesin 2 (CYTH2) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cytohesin 2 (CYTH2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cytohesin 2 (CYTH2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cytohesin 2 (CYTH2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cytohesin 2 (CYTH2) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cytohesin 2 (CYTH2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cytohesin 2 (CYTH2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cytohesin 2 (CYTH2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cytohesin 2 (CYTH2) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cytohesin 2 (CYTH2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cytohesin 2 (CYTH2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cytohesin 2 (CYTH2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cytohesin 2 (CYTH2) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cytohesin 2 (CYTH2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cytohesin 2 (CYTH2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cytohesin 2 (CYTH2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cytohesin 2 (CYTH2) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cytohesin 2 (CYTH2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cytohesin 2 (CYTH2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cytohesin 2 (CYTH2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cytohesin 2 (CYTH2) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cytohesin 2 (CYTH2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cytohesin 2 (CYTH2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cytohesin 2 (CYTH2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cytohesin 2 (CYTH2) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cytohesin 2 (CYTH2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cytohesin 2 (CYTH2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cytohesin 2 (CYTH2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cytohesin 2 (CYTH2) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cytohesin 2 (CYTH2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cytohesin 2 (CYTH2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cytohesin 2 (CYTH2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cytohesin 2 (CYTH2) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cytohesin 2 (CYTH2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cytohesin 2 (CYTH2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cytohesin 2 (CYTH2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cytohesin 2 (CYTH2) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cytohesin 2 (CYTH2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cytohesin 2 (CYTH2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cytohesin 2 (CYTH2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cytohesin 2 (CYTH2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cytohesin 2 (CYTH2) CLIA assay for Antigen Detection
Reference
"A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains." Nature 384:481-484(1996) [PubMed ] [Europe PMC ] [Abstract ]
"ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6." J. Biol. Chem. 273:23-27(1998) [PubMed ] [Europe PMC ] [Abstract ]
"Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed ] [Europe PMC ] [Abstract ]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14:2121-2127(2004) [PubMed ] [Europe PMC ] [Abstract ]
"The calcium-sensing receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein network." J. Cell Sci. 120:2489-2497(2007) [PubMed ] [Europe PMC ] [Abstract ]
"The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane." Curr. Biol. 17:711-716(2007) [PubMed ] [Europe PMC ] [Abstract ]
"Arf6 guanine nucleotide exchange factor cytohesin-2 binds to CCDC120 and is transported along neurites to mediate neurite growth." J. Biol. Chem. 289:33887-33903(2014) [PubMed ] [Europe PMC ] [Abstract ]
"Structure of the guanine nucleotide exchange factor Sec7 domain of human ARNO and analysis of the interaction with ARF GTPase." Cell 92:415-423(1998) [PubMed ] [Europe PMC ] [Abstract ]
"Structure of the Sec7 domain of the Arf exchange factor ARNO." Nature 392:101-105(1998) [PubMed ] [Europe PMC ] [Abstract ]
"Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor." Nature 426:525-530(2003) [PubMed ] [Europe PMC ] [Abstract ]
