Call Now

Integrin Linked Kinase (ILK)

ILK1; P59; 59 kDa serine/threonine-protein kinase

Integrin-linked kinase (ILK) is a 59kDa protein originally identified while conducting a yeast-two hybrid screen with integrin beta 1 as the bait protein. Since its discovery, ILK has been associated with multiple cellular functions including cell migration, cell proliferation, cell-adhesions, signal transduction. Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V248Hu01 Recombinant Integrin Linked Kinase (ILK) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Linked Kinase (ILK) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IP.
PV248Hu01 Polyclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Linked Kinase (ILK) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Linked Kinase (ILK) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Linked Kinase (ILK) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Linked Kinase (ILK) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Linked Kinase (ILK) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Linked Kinase (ILK) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Linked Kinase (ILK) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Linked Kinase (ILK) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Linked Kinase (ILK) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Linked Kinase (ILK) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Linked Kinase (ILK) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Linked Kinase (ILK) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Linked Kinase (ILK) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Linked Kinase (ILK) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Linked Kinase (ILK) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Linked Kinase (ILK) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Linked Kinase (ILK) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Linked Kinase (ILK) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Linked Kinase (ILK) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Linked Kinase (ILK) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Linked Kinase (ILK) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Linked Kinase (ILK) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Linked Kinase (ILK) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Linked Kinase (ILK) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Linked Kinase (ILK) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Linked Kinase (ILK) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Linked Kinase (ILK) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Linked Kinase (ILK) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Linked Kinase (ILK) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Linked Kinase (ILK) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Linked Kinase (ILK) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Linked Kinase (ILK) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Linked Kinase (ILK) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Linked Kinase (ILK) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Linked Kinase (ILK) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Linked Kinase (ILK) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Linked Kinase (ILK) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Linked Kinase (ILK) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Linked Kinase (ILK) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Linked Kinase (ILK) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Linked Kinase (ILK) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Linked Kinase (ILK) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Linked Kinase (ILK) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Linked Kinase (ILK) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Linked Kinase (ILK) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Linked Kinase (ILK) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Linked Kinase (ILK) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Linked Kinase (ILK) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Linked Kinase (ILK) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Linked Kinase (ILK) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Integrin Linked Kinase (ILK) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Integrin Linked Kinase (ILK) Bioactivity
Antibodies NONE Monoclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Integrin Linked Kinase (ILK) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Integrin Linked Kinase (ILK) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Integrin Linked Kinase (ILK) CLIA assay for Antigen Detection

Reference

"Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase."
Nature 379:91-96(1996) [PubMed] [Europe PMC] [Abstract]

"Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation."
Oncogene 19:3069-3077(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase."
Proc. Natl. Acad. Sci. U.S.A. 95:11211-11216(1998) [PubMed] [Europe PMC] [Abstract]

"Cell-substrate interactions and signaling through ILK."
Curr. Opin. Cell Biol. 12:250-256(2000) [PubMed] [Europe PMC] [Abstract]

"A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction."
J. Cell Biol. 153:1251-1264(2001) [PubMed] [Europe PMC] [Abstract]

"Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration."
J. Biol. Chem. 277:38328-38338(2002) [PubMed] [Europe PMC] [Abstract]

"Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival."
J. Biol. Chem. 279:41695-41705(2004) [PubMed] [Europe PMC] [Abstract]

"EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility."
J. Cell Sci. 122:243-255(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"The structural basis of integrin-linked kinase-PINCH interactions."
Proc. Natl. Acad. Sci. U.S.A. 105:20677-20682(2008) [PubMed] [Europe PMC] [Abstract]

"Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase."
J. Biol. Chem. 284:5836-5844(2009) [PubMed] [Europe PMC] [Abstract]

"The pseudoactive site of ILK is essential for its binding to alpha-parvin and localization to focal adhesions."
Mol. Cell 36:819-830(2009) [PubMed] [Europe PMC] [Abstract]

"Structural basis for asymmetric association of the betaPIX coiled coil and shank PDZ."
J. Mol. Biol. 397:457-466(2010) [PubMed] [Europe PMC] [Abstract]

"Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells."
Circulation 116:515-525(2007) [PubMed] [Europe PMC] [Abstract]