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Interferon Regulatory Factor 3 (IRF3)

Interferon regulatory factor 3 is a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.

The IRF3 gene is present in a single copy in the human genome. Northern blot analysis detected a 1.6-kb constitutively expressed IRF3 transcript. The deduced 427-amino acid IRF3 protein is 34 to 40% identical to other members of the IRF family in the N-terminal region. Au et al. (1995) showed that IRF3 is a 50-kD protein.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V246Hu01 Recombinant Interferon Regulatory Factor 3 (IRF3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Interferon Regulatory Factor 3 (IRF3) Bioactivity
Antibodies MV246Hu22 Monoclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IP.
PV246Hu01 Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry;ICC/IF
Assay Kits KEV246Hu ELISA Kit for Interferon Regulatory Factor 3 (IRF3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Interferon Regulatory Factor 3 (IRF3) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V246Mu01 Recombinant Interferon Regulatory Factor 3 (IRF3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Interferon Regulatory Factor 3 (IRF3) Bioactivity
Antibodies NONE Monoclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IP.
PV246Mu01 Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry;ICC/IF
Assay Kits KEV246Mu ELISA Kit for Interferon Regulatory Factor 3 (IRF3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Interferon Regulatory Factor 3 (IRF3) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Interferon Regulatory Factor 3 (IRF3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Interferon Regulatory Factor 3 (IRF3) Bioactivity
Antibodies NONE Monoclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Interferon Regulatory Factor 3 (IRF3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Interferon Regulatory Factor 3 (IRF3) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Interferon Regulatory Factor 3 (IRF3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Interferon Regulatory Factor 3 (IRF3) Bioactivity
Antibodies NONE Monoclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Interferon Regulatory Factor 3 (IRF3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Interferon Regulatory Factor 3 (IRF3) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Interferon Regulatory Factor 3 (IRF3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Interferon Regulatory Factor 3 (IRF3) Bioactivity
Antibodies NONE Monoclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Interferon Regulatory Factor 3 (IRF3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Interferon Regulatory Factor 3 (IRF3) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Interferon Regulatory Factor 3 (IRF3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Interferon Regulatory Factor 3 (IRF3) Bioactivity
Antibodies NONE Monoclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Interferon Regulatory Factor 3 (IRF3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Interferon Regulatory Factor 3 (IRF3) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Interferon Regulatory Factor 3 (IRF3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Interferon Regulatory Factor 3 (IRF3) Bioactivity
Antibodies NONE Monoclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Interferon Regulatory Factor 3 (IRF3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Interferon Regulatory Factor 3 (IRF3) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Interferon Regulatory Factor 3 (IRF3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Interferon Regulatory Factor 3 (IRF3) Bioactivity
Antibodies NONE Monoclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Interferon Regulatory Factor 3 (IRF3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Interferon Regulatory Factor 3 (IRF3) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Interferon Regulatory Factor 3 (IRF3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Interferon Regulatory Factor 3 (IRF3) Bioactivity
Antibodies NONE Monoclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Interferon Regulatory Factor 3 (IRF3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Interferon Regulatory Factor 3 (IRF3) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Interferon Regulatory Factor 3 (IRF3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Interferon Regulatory Factor 3 (IRF3) Bioactivity
Antibodies NONE Monoclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Interferon Regulatory Factor 3 (IRF3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Interferon Regulatory Factor 3 (IRF3) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Interferon Regulatory Factor 3 (IRF3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Interferon Regulatory Factor 3 (IRF3) Bioactivity
Antibodies NONE Monoclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Interferon Regulatory Factor 3 (IRF3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Interferon Regulatory Factor 3 (IRF3) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Interferon Regulatory Factor 3 (IRF3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Interferon Regulatory Factor 3 (IRF3) Bioactivity
Antibodies NONE Monoclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Interferon Regulatory Factor 3 (IRF3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Interferon Regulatory Factor 3 (IRF3) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Interferon Regulatory Factor 3 (IRF3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Interferon Regulatory Factor 3 (IRF3) Bioactivity
Antibodies NONE Monoclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Interferon Regulatory Factor 3 (IRF3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Interferon Regulatory Factor 3 (IRF3) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Interferon Regulatory Factor 3 (IRF3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Interferon Regulatory Factor 3 (IRF3) Bioactivity
Antibodies NONE Monoclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Interferon Regulatory Factor 3 (IRF3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Interferon Regulatory Factor 3 (IRF3) CLIA assay for Antigen Detection

Reference

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Proc. Natl. Acad. Sci. U.S.A. 92:11657-11661(1995) [PubMed] [Europe PMC] [Abstract]

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker."
Ann. Hum. Genet. 62:231-234(1998) [PubMed] [Europe PMC] [Abstract]

"Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation."
Mol. Cell. Biol. 18:2986-2996(1998) [PubMed] [Europe PMC] [Abstract]

"Analyses of virus-induced homomeric and heteromeric protein associations between IRF-3 and coactivator CBP/p300."
J. Biochem. 128:301-307(2000) [PubMed] [Europe PMC] [Abstract]

"Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1."
Mol. Cell. Biol. 20:4159-4168(2000) [PubMed] [Europe PMC] [Abstract]

"Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3."
J. Biol. Chem. 276:355-363(2001) [PubMed] [Europe PMC] [Abstract]

"IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein."
J. Biol. Chem. 276:8951-8957(2001) [PubMed] [Europe PMC] [Abstract]

"HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators."
Oncogene 20:800-811(2001) [PubMed] [Europe PMC] [Abstract]

"Control of IRF-3 activation by phosphorylation."
J. Interferon Cytokine Res. 22:73-76(2002) [PubMed] [Europe PMC] [Abstract]

"A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling."
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"Interferon regulatory factor 3 is a cellular partner of rotavirus NSP1."
J. Virol. 76:9545-9550(2002) [PubMed] [Europe PMC] [Abstract]

"LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF."
J. Exp. Med. 198:1043-1055(2003) [PubMed] [Europe PMC] [Abstract]

Erratum
J. Exp. Med. 198:1451-1451(2003)

"Triggering the interferon antiviral response through an IKK-related pathway."
Science 300:1148-1151(2003) [PubMed] [Europe PMC] [Abstract]

"Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways."
J. Biol. Chem. 279:15652-15661(2004) [PubMed] [Europe PMC] [Abstract]

"SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways."
EMBO J. 24:4018-4028(2005) [PubMed] [Europe PMC] [Abstract]

"VISA is an adapter protein required for virus-triggered IFN-beta Signaling."
Mol. Cell 19:727-740(2005) [PubMed] [Europe PMC] [Abstract]

"Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages."
Biochem. Pharmacol. 72:1469-1476(2006) [PubMed] [Europe PMC] [Abstract]

"Type I interferon gene induction by the interferon regulatory factor family of transcription factors."
Immunity 25:349-360(2006) [PubMed] [Europe PMC] [Abstract]

Erratum
Immunity 25:849-849(2006)

"Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3."
Cell Res. 18:1096-1104(2008) [PubMed] [Europe PMC] [Abstract]

"The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3."
J. Immunol. 181:1780-1786(2008) [PubMed] [Europe PMC] [Abstract]

"Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1."
J. Virol. 83:3069-3077(2009) [PubMed] [Europe PMC] [Abstract]

"Regulation of immunity and oncogenesis by the IRF transcription factor family."
Cancer Immunol. Immunother. 59:489-510(2010) [PubMed] [Europe PMC] [Abstract]

"Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification."
Mol. Cell. Biol. 30:2424-2436(2010) [PubMed] [Europe PMC] [Abstract]

"Human DEAD box helicase 3 couples IkappaB kinase epsilon to interferon regulatory factor 3 activation."
Mol. Cell. Biol. 33:2004-2015(2013) [PubMed] [Europe PMC] [Abstract]

"Structural insights into the functions of TBK1 in innate antimicrobial immunity."
Structure 21:1137-1148(2013) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"X-ray crystal structure of IRF-3 and its functional implications."
Nat. Struct. Biol. 10:922-927(2003) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation."
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"Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer."
EMBO J. 23:4384-4393(2004) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of IRF-3 in complex with CBP."
Structure 13:1269-1277(2005) [PubMed] [Europe PMC] [Abstract]