Interferon Regulatory Factor 5 (IRF5)

SPN	V237
HGNC	6120
MGI	1350924
PubMed	21240265
RGD	1310447
UniProt	Q13568
Wiki	IRF5

Interferon regulatory factor 5 is a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative splice variants encoding different isoforms exist.

Barnes et al. (2002) determined that herpes simplex virus, vesicular stomatitis virus, and NDV can activate IRF5 to induce varying amounts of different subtypes of biologically active IFNA. They found that, in addition to IFNA, IRF5 stimulates transcription of numerous inflammatory proteins in a virus-specific manner.

Reference

"Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes."
J. Biol. Chem. 276:23382-23390(2001) [PubMed] [Europe PMC] [Abstract]

"The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling."
J. Biol. Chem. 280:17005-17012(2005) [PubMed] [Europe PMC] [Abstract]

"Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function."
J. Biol. Chem. 280:21078-21090(2005) [PubMed] [Europe PMC] [Abstract]

"A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus."
Nat. Genet. 38:550-555(2006) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 7: DNA sequence and biology."
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes."
Mol. Cell. Biol. 22:5721-5740(2002) [PubMed] [Europe PMC] [Abstract]

"Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus."
Am. J. Hum. Genet. 76:528-537(2005) [PubMed] [Europe PMC] [Abstract]

"A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization."
J. Biol. Chem. 280:3088-3095(2005) [PubMed] [Europe PMC] [Abstract]

"Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis."
Arthritis Rheum. 56:2202-2210(2007) [PubMed] [Europe PMC] [Abstract]

"An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases."
Hum. Mol. Genet. 16:3008-3016(2007) [PubMed] [Europe PMC] [Abstract]

"Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination."
Mol. Cell. Biol. 28:7296-7308(2008) [PubMed] [Europe PMC] [Abstract]

"Activation of interferon regulatory factor 5 by site specific phosphorylation."
PLoS ONE 7:E33098-E33098(2012) [PubMed] [Europe PMC] [Abstract]

"Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5."
Nat. Struct. Mol. Biol. 15:1213-1220(2008) [PubMed] [Europe PMC] [Abstract]