Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1)
GR; GCCR; GCR; GR; GRL; NR3-C1; Glucocorticoid Receptor
The GR is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins.
The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV227Hu01 | Recombinant Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV227Hu01 | Monoclonal Antibody to Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | WB; IHC; ICC; IP. |
| PAV227Hu01 | Polyclonal Antibody to Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV227Hu01 | CLIA Kit for Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | CLIA assay for Antigen Detection |
| ELV227Hu01 | ELISA Kit for Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV227Mu01 | Recombinant Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV227Mu01 | Monoclonal Antibody to Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | WB; IHC; ICC; IP. |
| PAV227Mu01 | Polyclonal Antibody to Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV227Mu01 | CLIA Kit for Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | CLIA assay for Antigen Detection |
| ELV227Mu01 | ELISA Kit for Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV227Ra01 | Recombinant Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV227Ra01 | Monoclonal Antibody to Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | WB; IHC; ICC; IP. |
| PAV227Ra01 | Polyclonal Antibody to Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV227Ra01 | CLIA Kit for Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | CLIA assay for Antigen Detection |
| ELV227Ra01 | ELISA Kit for Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV227Ca01 | Recombinant Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV227Ca01 | Monoclonal Antibody to Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | WB; IHC; ICC; IP. |
| PAV227Ca01 | Polyclonal Antibody to Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV227Ca01 | CLIA Kit for Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | CLIA assay for Antigen Detection |
| ELV227Ca01 | ELISA Kit for Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV227Po01 | Recombinant Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV227Po01 | Monoclonal Antibody to Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | WB; IHC; ICC; IP. |
| PAV227Po01 | Polyclonal Antibody to Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV227Po01 | CLIA Kit for Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | CLIA assay for Antigen Detection |
| ELV227Po01 | ELISA Kit for Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV227Bo01 | Recombinant Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV227Bo01 | Monoclonal Antibody to Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | WB; IHC; ICC; IP. |
| PAV227Bo01 | Polyclonal Antibody to Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV227Bo01 | CLIA Kit for Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | CLIA assay for Antigen Detection |
| ELV227Bo01 | ELISA Kit for Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV227Rb01 | Recombinant Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV227Rb01 | Monoclonal Antibody to Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | WB; IHC; ICC; IP. |
| PAV227Rb01 | Polyclonal Antibody to Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV227Rb01 | CLIA Kit for Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | CLIA assay for Antigen Detection |
| ELV227Rb01 | ELISA Kit for Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV227Mo01 | Recombinant Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV227Mo01 | Monoclonal Antibody to Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | WB; IHC; ICC; IP. |
| PAV227Mo01 | Polyclonal Antibody to Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV227Mo01 | CLIA Kit for Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | CLIA assay for Antigen Detection |
| ELV227Mo01 | ELISA Kit for Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Primary structure and expression of a functional human glucocorticoid receptor cDNA."
Nature 318:635-641(1985) [PubMed] [Europe PMC] [Abstract]
"The genomic structure of the human glucocorticoid receptor."
J. Biol. Chem. 266:7182-7188(1991) [PubMed] [Europe PMC] [Abstract]
"Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
"A new transcript splice variant of the human glucocorticoid receptor: identification and tissue distribution of hGR Delta 313-338, an alternative exon 2 transactivation domain isoform."
Ann. N. Y. Acad. Sci. 1095:334-341(2007) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Purification of a human glucocorticoid receptor gene promoter-binding protein. Production of polyclonal antibodies against the purified factor."
J. Biol. Chem. 266:8711-8719(1991) [PubMed] [Europe PMC] [Abstract]
"Human glucocorticoid receptor gene promotor-homologous down regulation."
J. Steroid Biochem. Mol. Biol. 40:317-323(1991) [PubMed] [Europe PMC] [Abstract]
"Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product."
Nature 318:670-672(1985) [PubMed] [Europe PMC] [Abstract]
"Alternatively spliced glucocorticoid receptor messenger RNAs in glucocorticoid-resistant human multiple myeloma cells."
Cancer Res. 53:3877-3879(1993) [PubMed] [Europe PMC] [Abstract]
"Role of the Ada adaptor complex in gene activation by the glucocorticoid receptor."
Mol. Cell. Biol. 17:3065-3073(1997) [PubMed] [Europe PMC] [Abstract]
"Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex."
Nature 393:88-91(1998) [PubMed] [Europe PMC] [Abstract]
"A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity."
J. Cell Biol. 146:929-940(1999) [PubMed] [Europe PMC] [Abstract]
"Insertion of an amino acid in the DNA-binding domain of the glucocorticoid receptor as a result of alternative splicing."
J. Clin. Endocrinol. Metab. 84:4283-4286(1999) [PubMed] [Europe PMC] [Abstract]
"Steroidogenic enzyme gene expression in the human heart."
J. Clin. Endocrinol. Metab. 85:2519-2525(2000) [PubMed] [Europe PMC] [Abstract]
"A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP."
Mol. Cell. Biol. 20:5048-5063(2000) [PubMed] [Europe PMC] [Abstract]
"Regulation of expanded polyglutamine protein aggregation and nuclear localization by the glucocorticoid receptor."
Proc. Natl. Acad. Sci. U.S.A. 97:657-661(2000) [PubMed] [Europe PMC] [Abstract]
"Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids."
J. Biol. Chem. 276:42714-42721(2001) [PubMed] [Europe PMC] [Abstract]
"High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids."
J. Exp. Med. 193:585-593(2001) [PubMed] [Europe PMC] [Abstract]
"Molecular identification and characterization of A and B forms of the glucocorticoid receptor."
Mol. Endocrinol. 15:1093-1103(2001) [PubMed] [Europe PMC] [Abstract]
"Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor."
Biochem. J. 367:907-911(2002) [PubMed] [Europe PMC] [Abstract]
"Deciphering the phosphorylation 'code' of the glucocorticoid receptor in vivo."
J. Biol. Chem. 277:26573-26580(2002) [PubMed] [Europe PMC] [Abstract]
"Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade."
Proc. Natl. Acad. Sci. U.S.A. 99:14783-14788(2002) [PubMed] [Europe PMC] [Abstract]
"The origin and functions of multiple human glucocorticoid receptor isoforms."
Ann. N. Y. Acad. Sci. 1024:102-123(2004) [PubMed] [Europe PMC] [Abstract]
"Distinct LIM domains of Hic-5/ARA55 are required for nuclear matrix targeting and glucocorticoid receptor binding and coactivation."
J. Cell. Biochem. 92:810-819(2004) [PubMed] [Europe PMC] [Abstract]
"HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b."
Proc. Natl. Acad. Sci. U.S.A. 102:8555-8560(2005) [PubMed] [Europe PMC] [Abstract]
"GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway."
Mol. Cell. Biol. 26:1722-1730(2006) [PubMed] [Europe PMC] [Abstract]
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications."
FASEB J. 23:1572-1583(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Glucocorticoids induce mitochondrial gene transcription in HepG2 cells: role of the mitochondrial glucocorticoid receptor."
Biochim. Biophys. Acta 1813:1814-1821(2011) [PubMed] [Europe PMC] [Abstract]
"The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress."
J. Biol. Chem. 286:30152-30160(2011) [PubMed] [Europe PMC] [Abstract]
"Cryptochromes mediate rhythmic repression of the glucocorticoid receptor."
Nature 480:552-556(2011) [PubMed] [Europe PMC] [Abstract]
"Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man."
PLoS ONE 6:E25612-E25612(2011) [PubMed] [Europe PMC] [Abstract]
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
"RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity."
Mol. Cell. Biol. 33:2116-2127(2013) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition."
Cell 110:93-105(2002) [PubMed] [Europe PMC] [Abstract]
"The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism."
J. Biol. Chem. 278:22748-22754(2003) [PubMed] [Europe PMC] [Abstract]
"Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance."
J. Clin. Invest. 87:680-686(1991) [PubMed] [Europe PMC] [Abstract]
"Cloning and expression of mutant glucocorticoid receptors from glucocorticoid-sensitive and -resistant human leukemic cells."
Cancer Res. 53:4059-4065(1993) [PubMed] [Europe PMC] [Abstract]
"Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene."
J. Clin. Endocrinol. Metab. 76:683-689(1993) [PubMed] [Europe PMC] [Abstract]
"A mutation of the glucocorticoid receptor in primary cortisol resistance."
J. Clin. Invest. 91:1918-1925(1993) [PubMed] [Europe PMC] [Abstract]
"Identification of the activation-labile gene: a single point mutation in the human glucocorticoid receptor presents as two distinct receptor phenotypes."
Mol. Endocrinol. 7:631-642(1993) [PubMed] [Europe PMC] [Abstract]
"Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance."
Hum. Genet. 99:663-668(1997) [PubMed] [Europe PMC] [Abstract]
"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
Erratum
Nat. Genet. 23:373-373(1999)
"Five missense variants in the amino-terminal domain of the glucocorticoid receptor: no association with puerperal psychosis or schizophrenia."
Am. J. Med. Genet. 96:412-417(2000) [PubMed] [Europe PMC] [Abstract]
"Characterization of two novel mutations in the glucocorticoid receptor gene in patients with primary cortisol resistance."
Clin. Endocrinol. (Oxf.) 55:363-371(2001) [PubMed] [Europe PMC] [Abstract]
"The N363S polymorphism of the glucocorticoid receptor: potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus."
J. Clin. Endocrinol. Metab. 86:2270-2274(2001) [PubMed] [Europe PMC] [Abstract]
"Pathologic human GR mutant has a transdominant negative effect on the wild-type GR by inhibiting its translocation into the nucleus: importance of the ligand-binding domain for intracellular GR trafficking."
J. Clin. Endocrinol. Metab. 86:5600-5608(2001) [PubMed] [Europe PMC] [Abstract]
"A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels."
Diabetes 51:3128-3134(2002) [PubMed] [Europe PMC] [Abstract]
"Female pseudohermaphroditism caused by a novel homozygous missense mutation of the GR gene."
J. Clin. Endocrinol. Metab. 87:1805-1809(2002) [PubMed] [Europe PMC] [Abstract]
"A novel, C-terminal dominant negative mutation of the GR causes familial glucocorticoid resistance through abnormal interactions with p160 steroid receptor coactivators."
J. Clin. Endocrinol. Metab. 87:2658-2667(2002) [PubMed] [Europe PMC] [Abstract]
"Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men."
Am. J. Med. 117:158-162(2004) [PubMed] [Europe PMC] [Abstract]
"The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults."
J. Clin. Endocrinol. Metab. 89:4004-4009(2004) [PubMed] [Europe PMC] [Abstract]
"A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity."
J. Clin. Endocrinol. Metab. 90:3696-3705(2005) [PubMed] [Europe PMC] [Abstract]
"A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance."
J. Clin. Endocrinol. Metab. 92:3986-3990(2007) [PubMed] [Europe PMC] [Abstract]