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Thymosin Beta 4 (Tb4)

TMSB4X; FX; PTMB4; TB4X; TMSB4; Thymosin,Beta 4,X-Linked; TB-500; Seraspenide; Hematopoietic system regulatory peptide

SPN V226
HGNC 11881
MGI 99510
PubMed 20536454
RGD 621622
UniProt P62328
Wiki TB4

The predominant form of thymosin, thymosin beta4, is a member of a highly conserved family of actin monomer-sequestering proteins. Beta-thymosins are the primary regulators of unpolymerized actin, and are essential for maintaining the small cytoplasmic pool of free G-actin monomers required for rapid filament elongation and allowing for the flux of monomers between the thymosin-bound pool and F-actin.

Thymosin beta4 sequesters actin, holding it in a form that is unable to polymerize. Due to its profusion in the cytosol and its ability to bind ATP G-actin but not F-actin, thymosin beta4 is regarded as the principal actin-sequestering protein. Thymosin beta4 binds ATP G- monomeric actin in a 11 complex where G-actin cannot polymerize.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V226Hu01 Recombinant Thymosin Beta 4 (Tb4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Thymosin Beta 4 (Tb4) Bioactivity
Antibodies MV226Hu21 Monoclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IP.
PV226Hu01 Polyclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IF.
LV226Hu71 Biotin Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Thymosin Beta 4 (Tb4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Thymosin Beta 4 (Tb4) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V226Mu01 Recombinant Thymosin Beta 4 (Tb4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Thymosin Beta 4 (Tb4) Bioactivity
Antibodies NONE Monoclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IP.
PV226Mu01 Polyclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IF.
LV226Mu71 Biotin Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry
LV226Mu81 FITC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Thymosin Beta 4 (Tb4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Thymosin Beta 4 (Tb4) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V226Ra01 Recombinant Thymosin Beta 4 (Tb4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Thymosin Beta 4 (Tb4) Bioactivity
Antibodies NONE Monoclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IP.
PV226Ra01 Polyclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Thymosin Beta 4 (Tb4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Thymosin Beta 4 (Tb4) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Thymosin Beta 4 (Tb4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Thymosin Beta 4 (Tb4) Bioactivity
Antibodies NONE Monoclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Thymosin Beta 4 (Tb4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Thymosin Beta 4 (Tb4) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Thymosin Beta 4 (Tb4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Thymosin Beta 4 (Tb4) Bioactivity
Antibodies NONE Monoclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Thymosin Beta 4 (Tb4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Thymosin Beta 4 (Tb4) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V226Bo01 Recombinant Thymosin Beta 4 (Tb4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Thymosin Beta 4 (Tb4) Bioactivity
Antibodies NONE Monoclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IP.
PV226Bo01 Polyclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IF.
LV226Bo71 Biotin Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Thymosin Beta 4 (Tb4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Thymosin Beta 4 (Tb4) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Thymosin Beta 4 (Tb4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Thymosin Beta 4 (Tb4) Bioactivity
Antibodies NONE Monoclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Thymosin Beta 4 (Tb4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Thymosin Beta 4 (Tb4) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Thymosin Beta 4 (Tb4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Thymosin Beta 4 (Tb4) Bioactivity
Antibodies NONE Monoclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Thymosin Beta 4 (Tb4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Thymosin Beta 4 (Tb4) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Thymosin Beta 4 (Tb4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Thymosin Beta 4 (Tb4) Bioactivity
Antibodies NONE Monoclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Thymosin Beta 4 (Tb4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Thymosin Beta 4 (Tb4) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Thymosin Beta 4 (Tb4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Thymosin Beta 4 (Tb4) Bioactivity
Antibodies NONE Monoclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Thymosin Beta 4 (Tb4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Thymosin Beta 4 (Tb4) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Thymosin Beta 4 (Tb4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Thymosin Beta 4 (Tb4) Bioactivity
Antibodies NONE Monoclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Thymosin Beta 4 (Tb4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Thymosin Beta 4 (Tb4) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V226Eq01 Recombinant Thymosin Beta 4 (Tb4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Thymosin Beta 4 (Tb4) Bioactivity
Antibodies NONE Monoclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IP.
PV226Eq01 Polyclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IF.
LV226Eq71 Biotin Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Thymosin Beta 4 (Tb4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Thymosin Beta 4 (Tb4) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Thymosin Beta 4 (Tb4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Thymosin Beta 4 (Tb4) Bioactivity
Antibodies NONE Monoclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Thymosin Beta 4 (Tb4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Thymosin Beta 4 (Tb4) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Thymosin Beta 4 (Tb4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Thymosin Beta 4 (Tb4) Bioactivity
Antibodies NONE Monoclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Thymosin Beta 4 (Tb4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Thymosin Beta 4 (Tb4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Thymosin Beta 4 (Tb4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Thymosin Beta 4 (Tb4) CLIA assay for Antigen Detection

Reference

"Differential expression of the human thymosin-beta 4 gene in lymphocytes, macrophages, and granulocytes."
J. Immunol. 139:3840-3848(1987) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and structural characterization of the functional human thymosin beta4 gene."
Mol. Cell. Biochem. 272:97-105(2005) [PubMed] [Europe PMC] [Abstract]

"Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable."
J. Biol. Chem. 266:4029-4032(1991) [PubMed] [Europe PMC] [Abstract]

"Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells."
Cell 38:745-755(1984) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Structural requirements for thymosin beta4 in its contact with actin. An NMR-analysis of thymosin beta4 mutants in solution and correlation with their biological activity."
Eur. J. Biochem. 267:3530-3538(2000) [PubMed] [Europe PMC] [Abstract]

"Structural states and dynamics of the D-loop in actin."
Biophys. J. 103:930-939(2012) [PubMed] [Europe PMC] [Abstract]

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