Coagulation Factor XIII B Polypeptide (F13B)

F13-B; FXIIIB; Fibrin-stabilizing factor B subunit; Protein-glutamine gamma-glutamyltransferase B chain; Transglutaminase B chain

SPN	V222
HGNC	3534
MGI	88379
PubMed	3471677
RGD	1311668
UniProt	P05160
Wiki	F13B

Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot.

Reference

"Nucleotide sequence of the gene for the b subunit of human factor XIII."
Biochemistry 29:11195-11209(1990) [PubMed] [Europe PMC] [Abstract]

"Amino acid sequence of the b subunit of human factor XIII, a protein composed of ten repetitive segments."
Biochemistry 25:4633-4638(1986) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"Complete cDNA sequence encoding the B subunit of human factor XIII."
Nucleic Acids Res. 18:2817-2817(1990) [PubMed] [Europe PMC] [Abstract]

"Truncated mutant B subunit for factor XIII causes its deficiency due to impaired intracellular transportation."
Blood 97:2667-2672(2001) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Two genetic defects in a patient with complete deficiency of the b-subunit for coagulation factor XIII."
Blood 82:145-150(1993) [PubMed] [Europe PMC] [Abstract]

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 23:373-373(1999)